C
Clara Depommier
Researcher at Université catholique de Louvain
Publications - 13
Citations - 3024
Clara Depommier is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Akkermansia muciniphila & Insulin resistance. The author has an hindex of 5, co-authored 10 publications receiving 1557 citations.
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Journal ArticleDOI
A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
Hubert Plovier,Amandine Everard,Céline Druart,Clara Depommier,Matthias Van Hul,Lucie Geurts,Julien Chilloux,Noora Ottman,Thibaut Duparc,Laeticia Lichtenstein,Antonis Myridakis,Nathalie M. Delzenne,Judith Klievink,Arnab Bhattacharjee,Kees C. H. van der Ark,Steven Aalvink,Laurent O. Martinez,Marc-Emmanuel Dumas,Dominique Maiter,Audrey Loumaye,Michel P. Hermans,Jean-Paul Thissen,Clara Belzer,Willem M. de Vos,Willem M. de Vos,Patrice D. Cani +25 more
TL;DR: It is shown that A. muciniphila retains its efficacy when grown on a synthetic medium compatible with human administration and enhanced its capacity to reduce fat mass development, insulin resistance and dyslipidemia in mice, and Amuc_1100, a specific protein isolated from the outer membrane of A. Sydneyi, interacts with Toll-like receptor 2, is stable at temperatures used for pasteurization and partly recapitulates the beneficial effects of the bacterium.
Journal ArticleDOI
Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study.
Clara Depommier,Amandine Everard,Céline Druart,Hubert Plovier,Matthias Van Hul,Sara Vieira-Silva,Gwen Falony,Jeroen Raes,Dominique Maiter,Nathalie M. Delzenne,Marie de Barsy,Audrey Loumaye,Michel P. Hermans,Jean-Paul Thissen,Willem M. de Vos,Willem M. de Vos,Patrice D. Cani +16 more
TL;DR: In this article, Akkermansia muciniphila, a gut microbe previously associated with metabolic health in preclinical models, is safe and well tolerated in humans and may improve metabolic parameters in overweight and obese patients.
Journal ArticleDOI
Microbial regulation of organismal energy homeostasis.
Patrice D. Cani,Matthias Van Hul,Charlotte Lefort,Clara Depommier,Marialetizia Rastelli,Amandine Everard +5 more
TL;DR: A large body of evidence is presented supporting the concept that gut microbiota-based therapies can be used to modulate host metabolism, and the authors expect to see such approaches moving from bench to bedside in the near future.
Journal ArticleDOI
Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice.
Clara Depommier,Matthias Van Hul,Amandine Everard,Nathalie M. Delzenne,Willem M. de Vos,Willem M. de Vos,Patrice D. Cani +6 more
TL;DR: The effects of pasteurized A. muciniphila on whole-body energy metabolism during high-fat diet feeding is investigated by using metabolic chambers and it is found that energy expenditure was enhanced independently from changes in markers of thermogenesis or beiging of the white adipose tissue.
Journal ArticleDOI
Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms
TL;DR: This Review covers the discovery of Akkermansia muciniphila and its association with health and disease, including metabolic diseases, and summarizes the numerous findings and main mechanisms of action by which this intestinal symbiont improves health.