Arnab Bhattacharjee

TL;DR: It is shown that A. muciniphila retains its efficacy when grown on a synthetic medium compatible with human administration and enhanced its capacity to reduce fat mass development, insulin resistance and dyslipidemia in mice, and Amuc_1100, a specific protein isolated from the outer membrane of A. Sydneyi, interacts with Toll-like receptor 2, is stable at temperatures used for pasteurization and partly recapitulates the beneficial effects of the bacterium.

TL;DR: It is shown that C3d could replace glycosaminoglycan binding to FH20, thus providing a feedback control for preventing excess C3b deposition and complement amplification, and explains the molecular basis of atypical hemolytic uremic syndrome.

TL;DR: Several high resolution crystal structures of oligopeptides related to collagen have been determined in the last ten years, which have confirmed the essential correctness of the coiled‐coil triple helical structure of collagen, as well as the role of water and hydroxyproline residues, but also indicated additional sequence‐dependent features.

TL;DR: This study reveals that seven microbes representing different phyla utilize a common binding site on the domain 20 of FH for complement evasion, which enhances function ofFH on the microbial surfaces via the novel mechanism of tripartite complex formation.

TL;DR: The data suggest that association of CF HR1 deficiency with autoimmune aHUS could be due to the structural difference between CFHR1 and the autoantigenic CFH epitope, suggesting a novel explanation for CFHR 1 deficiency in the pathogenesis of autoimmune ahUS.