Clarence R. Hurt

TL;DR: In this article, the crystal structures of Ret surrogates were determined using X-ray crystallography, and the use of such surrogate crystals and strucural information can be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.

TL;DR: In this paper, the authors describe pan-active compounds that are active on PPARs and methods for developing or identifying compounds having a desired selectivity profile, including panactive compounds.

TL;DR: A highly specific dual FMS and KIT kinase inhibitor developed from a multifaceted chemical scaffold blocks the activation of macrophages, osteoclasts, and mast cells controlled by these two receptors.

TL;DR: These studies advance an alternate view of capsid formation (as a host-catalyzed biochemical pathway), a different paradigm for drug discovery (whole pathway screening without knowledge of the target), and suggest the existence of labile assembly machines that can be rendered accessible as next-generation drug targets by the means described.

TL;DR: In this article, the 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment of C-kit-mediate diseases or conditions, and methods of use thereof, are provided.