M. Dharma Prasad

TL;DR: Biotinylation reveals a 32-kDa, covalently cross-linked S OD1-containing protein species produced not only in FALS caused by SOD1 mutation, but also in SALS, suggesting a common step in the pathogenesis between SALS and FALS.

TL;DR: These studies advance an alternate view of capsid formation (as a host-catalyzed biochemical pathway), a different paradigm for drug discovery (whole pathway screening without knowledge of the target), and suggest the existence of labile assembly machines that can be rendered accessible as next-generation drug targets by the means described.

TL;DR: This work proposes these novel drug targets to comprise a previously unappreciated molecular basis for homeostasis that is modified by viruses to allow exploitation for viral propagation and is restored by treatment with the therapeutic compounds presented.