C
Claude A. Quesnelle
Researcher at Bristol-Myers Squibb
Publications - 36
Citations - 592
Claude A. Quesnelle is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Chemistry & BET inhibitor. The author has an hindex of 12, co-authored 34 publications receiving 535 citations.
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Patent
Pyrimidine inhibitors of phosphodiesterase (pde) 7
Junqing Guo,Joseph Barbosa,William J. Pitts,Marianne Carlsen,Claude A. Quesnelle,Marco Dodier +5 more
TL;DR: Pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula [insert chemical structure here] wherein R1, R2, Z, J and L are described in this paper and analogs thereof are provided which are useful in treating T-cell mediated diseases.
Journal ArticleDOI
Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.
Ashvinikumar V. Gavai,Claude A. Quesnelle,Derek J. Norris,Wen-Ching Han,Patrice Gill,Weifang Shan,Aaron Balog,Ke Chen,Andrew J. Tebben,Richard Rampulla,Dauh-Rurng Wu,Yingru Zhang,Arvind Mathur,Ronald E. White,Anne Rose,Haiqing Wang,Zheng Yang,Asoka Ranasinghe,Celia D’Arienzo,Victor R. Guarino,Lan Xiao,Ching Su,Gerry Everlof,Vinod Arora,Ding Ren Shen,Mary Ellen Cvijic,Krista Menard,Mei-Li Wen,Jere E. Meredith,George L. Trainor,Louis J. Lombardo,Richard E. Olson,Phil S. Baran,John T. Hunt,Gregory D. Vite,Bruce S. Fischer,Richard A. Westhouse,Francis Y. Lee +37 more
TL;DR: Structure-activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides identified highly potent inhibitors of γ-secretase mediated signaling of Notch1/2/3/4 receptors selected as a candidate for clinical evaluation.
Journal ArticleDOI
Sordaricin antifungal agents
Claude A. Quesnelle,Patrice Gill,Marco Dodier,Denis R. St. Laurent,Michael H. Serrano-Wu,Anne Marinier,Alain Martel,Charles E. Mazzucco,Terry M. Stickle,John F. Barrett,Dolatrai M. Vyas,Balu Balasubramanian +11 more
TL;DR: The synthesis of homologated sordaricin as well as ether and ester derivatives is presented, and structural rearrangement products upon oxidation were evaluated as agents to inhibit fungal growth.
Patent
Bis(fluoroalkyl)-1,4-benzodiazepinone compounds
TL;DR: In this article, compounds of Formula (I) or prodrugs thereof are defined, and methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds.
Journal ArticleDOI
Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.
Lawrence B. Snyder,Zhaoxing Meng,Robert A. Mate,Stanley D'andrea,Anne Marinier,Claude A. Quesnelle,Patrice Gill,Kenneth DenBleyker,Joan Fung-Tomc,MaryBeth Frosco,Alain Martel,John F. Barrett,Joanne J. Bronson +12 more
TL;DR: The synthesis and antibacterial activity of three potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring, the benzisoxazolones, pyrroles, and isoxazolinones is described.