Claude Hector Thilly

TL;DR: It is concluded that, contrary to the situation observed in physiological conditions, maternal thyroid function in regions of severe endemic goiter is a good indicator of newborn thyroid function.

TL;DR: Two months of selenium supplementation was shown to modify the serum thyroid hormones parameters in clinically euthyroid subjects and to induce a dramatic fall of the already impaired thyroid function in clinically hypothyroid subjects, further support a role of seenium in thyroid hormone metabolism.

TL;DR: In selenium-and-iodine-deficient humans, seenium supplementation may aggravate hypothyroidism by stimulating thyroxin metabolism by the selenoenzyme type I iodothyronine 5'-deiodinase.

TL;DR: One concludes that severe goiter has a multifactorial origin and IDD are a good model to study the effects of other trace elements whose actions in many human metabolisms have been somewhat underestimated.

TL;DR: It is concluded that iodine supplementation restored a biochemically euthyroid state in all younger children with cretinism but only some of the older children.