J
Jacques Emile Dumont
Researcher at Université libre de Bruxelles
Publications - 610
Citations - 31234
Jacques Emile Dumont is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Thyroid & Thyroglobulin. The author has an hindex of 83, co-authored 605 publications receiving 30221 citations. Previous affiliations of Jacques Emile Dumont include Free University of Brussels & Northwestern University.
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Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas
Jasmine Parma,Laurence Duprez,Jacqueline Van Sande,Pascale Cochaux,Christine Gervy,J. Mockel,Jacques Emile Dumont,Gilbert Vassart +7 more
TL;DR: Somatic mutations in the carboxv-terminal portion of the third cytoplasmic loop of the thyrotropin receptor are identified in three out of eleven hyperfunctioning thyroid adenomas, showing that G-protein-coupled receptors are susceptible to constitutive activation by spontaneous somatic mutations and may thus behave as proto-oncogenes.
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Selective amplification and cloning of four new members of the G protein-coupled receptor family.
Frédérick Libert,Marc Parmentier,Anne Lefort,Christiane Dinsart,J. Van Sande,Carine Maenhaut,Marie-Jeanne Simons,Jacques Emile Dumont,Gilbert Vassart +8 more
TL;DR: An approach based on the polymerase chain reaction has been devised to clone new members of the family of genes encoding guanosine triphosphate-binding protein (G protein)-coupled receptors, suggesting that they are members of a new subfamily of receptors with a very short nonglycosylated amino-terminal extension.
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The thyrotropin receptor and the regulation of thyrocyte function and growth.
TL;DR: The main regulation of the thyroid gland involves a positive control by pituitary TSH, which is generated in these cells from plasma T4 (1, 2) as discussed by the authors.
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Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
Xavier De Deken,Dantong Wang,Marie-Christine Many,Sabine Costagliola,Frédérick Libert,Gilbert Vassart,Jacques Emile Dumont,Françoise Miot +7 more
TL;DR: Two cDNAs encoding NADPH oxidases and constituting the thyroid H2O2 generating system have been cloned and the dog mRNA expression is thyroid-specific and up-regulated by agents activating the cAMP pathway as is the synthesis of the polypeptides they are coding for.
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Most random gene expression signatures are significantly associated with breast cancer outcome.
TL;DR: Surprisingly, it was found that gene expression signatures—unrelated to cancer—of the effect of postprandial laughter, of mice social defeat and of skin fibroblast localization were all significantly associated with breast cancer outcome.