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Claudia D. Lovell
Researcher at University of Pennsylvania
Publications - 3
Citations - 147
Claudia D. Lovell is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Metabolic pathway & Metabolomics. The author has an hindex of 2, co-authored 3 publications receiving 51 citations.
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Journal ArticleDOI
Compartmentalised acyl-CoA metabolism and roles in chromatin regulation.
TL;DR: The metabolic pathways that produce acyl-CoAs, as well as emerging evidence for functional roles of diverse acyl -CoAs in chromatin regulation, are reviewed, aiming to illuminate key questions in acy-CoA metabolism as they relate to the control of chromatin modification.
Journal ArticleDOI
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation
Ahmed Hassanein,Sophie Trefely,Sophie Trefely,Katharina Huber,Katharina Huber,Joyce Liu,Michael Noji,Stephanie Stransky,Jay Singh,Mary T. Doan,Claudia D. Lovell,Eliana von Krusenstiern,Helen Jiang,Anna Bostwick,Hannah L. Pepper,Luke Izzo,Steven Zhao,Jimmy P. Xu,Kenneth C. Bedi,J. Eduardo Rame,Juliane G. Bogner-Strauss,Clementina Mesaros,Simone Sidoli,Kathryn E. Wellen,Nathaniel W. Snyder +24 more
TL;DR: In this paper, stable isotope labeling of essential nutrients in cell culture-subcellular fractionation (SILEC-SF) was developed to quantify acyl-coenzyme A (acyl-CoA) thioesters in subcellular compartments by liquid chromatography-mass spectrometry.
Posted ContentDOI
Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation
Sophie Trefely,Sophie Trefely,Katharina Huber,Katharina Huber,Joyce Liu,Michael Noji,Stephanie Stransky,Jay Singh,Mary T. Doan,Claudia D. Lovell,Eliana von Krusenstiern,Helen Jiang,Anna Bostwick,Hannah L. Pepper,Luke Izzo,Steven Zhao,Jimmy P. Xu,Kenneth Bedi,J. Eduardo Rame,Juliane G. Bogner-Strauss,Clementina Mesaros,Simone Sidoli,Kathryn E. Wellen,Nathaniel W. Snyder +23 more
TL;DR: The SILEC-SF method is presented as a flexible approach for quantitative sub-cellular metabolic analyses and found that the mevalonate pathway intermediate 3-Hydroxy-3-methylglutaryl-CoA is exquisitely sensitive to acetyl- CoA supply.