K
Kathryn E. Wellen
Researcher at University of Pennsylvania
Publications - 96
Citations - 15956
Kathryn E. Wellen is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Acetylation & ATP citrate lyase. The author has an hindex of 33, co-authored 82 publications receiving 13284 citations. Previous affiliations of Kathryn E. Wellen include Harvard University.
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Inflammation, stress, and diabetes
TL;DR: The molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes are discussed.
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Obesity-induced inflammatory changes in adipose tissue
TL;DR: This issue of the JCI reports that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue.
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ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
Kathryn E. Wellen,Georgia Hatzivassiliou,Uma M. Sachdeva,Thi Bui,Justin R. Cross,Craig B. Thompson +5 more
TL;DR: It is found that ACL is required for increases in histone acetylation in response to growth factor stimulation and during differentiation, and that glucose availability can affect hist one acetylations in an ACL-dependent manner.
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IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lu,Patrick S. Ward,Patrick S. Ward,Gurpreet S. Kapoor,Dan Rohle,Dan Rohle,Sevin Turcan,Omar Abdel-Wahab,Christopher R. Edwards,Raya Khanin,Maria E. Figueroa,Ari Melnick,Kathryn E. Wellen,Donald M. O'Rourke,Shelley L. Berger,Timothy A. Chan,Ross L. Levine,Ingo K. Mellinghoff,Ingo K. Mellinghoff,Craig B. Thompson +19 more
TL;DR: It is reported that 2HG-producing IDH mutants can prevent the histone demethylation that is required for lineage-specific progenitor cells to differentiate into terminally differentiated cells, and that inhibition of histone methylation can be sufficient to block the differentiation of non-transformed cells.
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Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation
Joyce V. Lee,Alessandro Carrer,Supriya Shah,Nathaniel W. Snyder,Shuanzeng Wei,Sriram Venneti,Andrew J. Worth,Zuo-Fei Yuan,Hee-Woong Lim,Shichong Liu,Ellen Jackson,Nicole M. Aiello,Naomi B. Haas,Timothy R. Rebbeck,Alexander R. Judkins,Kyoung-Jae Won,Lewis A. Chodosh,Benjamin A. Garcia,Ben Z. Stanger,Michael Feldman,Ian A. Blair,Kathryn E. Wellen +21 more
TL;DR: It is demonstrated that acetyl-CoA is dynamically regulated by glucose availability in cancer cells and that the ratio of acetyl -CoA:coenzyme A within the nucleus modulates global histone acetylation levels.