C
Claudia Mitchell
Researcher at French Institute of Health and Medical Research
Publications - 28
Citations - 1668
Claudia Mitchell is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hepatocyte & Liver regeneration. The author has an hindex of 19, co-authored 28 publications receiving 1506 citations. Previous affiliations of Claudia Mitchell include University of Paris & Paris Descartes University.
Papers
More filters
Journal ArticleDOI
A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
TL;DR: A protocol and a movie describing a straightforward surgical technique, which takes 15–20 min, to consistently remove two-thirds of the liver in mice are provided and it is hoped that it will be widely used and serve to standardize 2/3 PH in mice.
Journal ArticleDOI
Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice
Claudia Mitchell,Claudia Mitchell,Dominique Couton,Dominique Couton,Jean-Pierre Couty,Jean-Pierre Couty,Jean-Pierre Couty,Marie Anson,Marie Anson,Marie Anson,Anne-Marie Crain,Anne-Marie Crain,Anne-Marie Crain,Vinciane Bizet,Vinciane Bizet,Laurent Rénia,Laurent Rénia,Laurent Rénia,Stanislas Pol,Stanislas Pol,Vincent Mallet,Vincent Mallet,Hélène Gilgenkrantz,Hélène Gilgenkrantz +23 more
TL;DR: Findings underline the role of the CCR2 signaling pathway in both the constitution and resolution of liver fibrotic scars in mutant animals.
Journal ArticleDOI
Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes
Alexandre Mignon,Jacques E. Guidotti,Claudia Mitchell,Monique Fabre,Anne Wernet,Alix de La Coste,Olivier Soubrane,Hélène Gilgenkrantz,Axel Kahn +8 more
TL;DR: A method for increasing genetic reconstitution of the liver through selective repopulation with modified transgenic hepatocytes, which will allow optimization of cell and gene therapy in the liver.
Journal ArticleDOI
Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo.
Vincent Mallet,Claudia Mitchell,Eva Mezey,Monique Fabre,Jacques-Emmanuel Guidotti,Laurent Rénia,Laure Coulombel,Axel Kahn,Hélène Gilgenkrantz +8 more
TL;DR: It is concluded that a selection strategy will be required to achieve a therapeutic level of liver repopulation with bone marrow–derived hepatocytes, and a strategy based on the protective effect of Bcl‐2 against Fas‐mediated apoptosis to selectively amplify a small number of hepatocytes in vivo.
Journal ArticleDOI
S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy
Catherine Espeillac,Claudia Mitchell,Claudia Mitchell,Séverine Celton-Morizur,Séverine Celton-Morizur,Céline Chauvin,Céline Chauvin,Vonda Koka,Vonda Koka,Cynthia Gillet,Cynthia Gillet,Jeffrey H. Albrecht,Chantal Desdouets,Chantal Desdouets,Mario Pende,Mario Pende +15 more
TL;DR: It was found that S6K1 controlled steady-state levels of cyclin D1 (Ccnd1) mRNA in liver, and cyclinD1 expression was required to promote hepatocyte cell cycle, and in vivo overexpression of cycl in vivo was sufficient to restore the proliferative capacity of S 6K-null livers.