C
Claudia Sievers
Researcher at Free University of Berlin
Publications - 4
Citations - 1734
Claudia Sievers is an academic researcher from Free University of Berlin. The author has contributed to research in topics: RNA interference & Stem cell. The author has an hindex of 2, co-authored 2 publications receiving 1677 citations. Previous affiliations of Claudia Sievers include Massachusetts Institute of Technology.
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Journal ArticleDOI
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Douglas A. Rubinson,Christopher P. Dillon,Adam V. Kwiatkowski,Claudia Sievers,Claudia Sievers,Lili Yang,Johnny E. Kopinja,Dina L Rooney,Mingdi Zhang,Melanie Ihrig,Michael T. McManus,Frank B. Gertler,Martin L. Scott,Luk Van Parijs +13 more
TL;DR: It is shown that lentivirus-delivered shRNAs are capable of specific, highly stable and functional silencing of gene expression in a variety of cell types and also in transgenic mice.
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SARS-CoV-2 Omicron variants BA.1 and BA.2 both show similarly reduced disease severity of COVID-19 compared to Delta, Germany, 2021 to 2022
Claudia Sievers,Benedikt Zacher,Alexander Ullrich,Matthew R. Huska,S. Fuchs,Silke Buda,Walter Haas,Michaela Diercke,Matthias an der Heiden,Stefan Kröger +9 more
TL;DR: German national surveillance data analysis shows that hospitalisation odds associated with Omicron lineage BA.1 or BA.2 infections are up to 80% lower than with Delta infection, primarily in ≥ 35-year-olds, suggesting that Omicrons inherently causes less severe disease.
Journal ArticleDOI
Correction: Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Douglas A. Rubinson,Christopher P. Dillon,Adam V. Kwiatkowski,Claudia Sievers,Lili Yang,Johnny E. Kopinja,Mingdi Zhang,Michael T. McManus,Frank B. Gertler,Martin L. Scott,Luk Van Parijs +10 more
TL;DR: The authors showed that primary activated T cells can be successfully transduced by lentivirus and that RNAi-targeted surface markers are downregulated in transduces cells.
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Plasma neurofilament light, glial fibrillary acidic protein and lysosphingolipid biomarkers for pharmacodynamics and disease monitoring of GM2 and GM1 gangliosidoses patients
Richard W.D. Welford,Hervé Farine,Michel Steiner,Marco Garzotti,Kostantin Dobrenis,Claudia Sievers,Daniel S. Strasser,Yasmina Amraoui,Peter M.A. Groenen,Roberto Giugliani,Eugen Mengel +10 more
TL;DR: In this article , lysosphingolipid and protein biomarkers were assessed in plasma samples from 33 GM2 gangliosidosis patients, 13 GM1 gangliosis patients, and compared to 66 controls.