M
Martin L. Scott
Researcher at Biogen Idec
Publications - 58
Citations - 17425
Martin L. Scott is an academic researcher from Biogen Idec. The author has contributed to research in topics: B-cell activating factor & B cell. The author has an hindex of 45, co-authored 58 publications receiving 16894 citations. Previous affiliations of Martin L. Scott include California Institute of Technology & University of Southern California.
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Production of high titer helper-free retroviruses by transient transfection
TL;DR: In this article, a method for producing high-titer, helper-free infectious retroviruses is disclosed which employs a novel strategy that uses transient transfection of new retroviral producer cell lines, ecotropic line BOSC 23 and amphotropic line CAK 8.
Journal ArticleDOI
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
TL;DR: A computational model is presented that describes the temporal control of NF-κB activation by the coordinated degradation and synthesis of IκB proteins and demonstrates that IπκBα is responsible for strong negative feedback that allows for a fast turn-off of the NF-σB response.
Journal ArticleDOI
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Douglas A. Rubinson,Christopher P. Dillon,Adam V. Kwiatkowski,Claudia Sievers,Claudia Sievers,Lili Yang,Johnny E. Kopinja,Dina L Rooney,Mingdi Zhang,Melanie Ihrig,Michael T. McManus,Frank B. Gertler,Martin L. Scott,Luk Van Parijs +13 more
TL;DR: It is shown that lentivirus-delivered shRNAs are capable of specific, highly stable and functional silencing of gene expression in a variety of cell types and also in transgenic mice.
Journal ArticleDOI
An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.
Barbara Schiemann,Jennifer L. Gommerman,Kalpit Vora,Teresa G. Cachero,Svetlana Shulga-Morskaya,Max Dobles,Erica M. Frew,Martin L. Scott +7 more
TL;DR: Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes, suggesting that BAFF plays a crucial role in B cell development and can function through receptors other than BCMA.
Journal ArticleDOI
BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
Jeffrey Thompson,Sarah A. Bixler,Fang Qian,Kalpit Vora,Martin L. Scott,Teresa G. Cachero,Catherine Hession,Pascal Schneider,Irene Sizing,Colleen Mullen,Kathy Strauch,Mohammad Zafari,Christopher D. Benjamin,Jürg Tschopp,Jeffrey L. Browning,Christine Ambrose +15 more
TL;DR: BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival and is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAff-deficient mice.