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Claudia U. Duerr
Researcher at McGill University
Publications - 12
Citations - 608
Claudia U. Duerr is an academic researcher from McGill University. The author has contributed to research in topics: Innate lymphoid cell & Immune system. The author has an hindex of 8, co-authored 12 publications receiving 482 citations.
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Journal ArticleDOI
Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells
Claudia U. Duerr,Connor D A McCarthy,Barbara C. Mindt,Manuel Rubio,Alexandre P. Meli,Julien Pothlichet,Megan M. Eva,Jean-François Gauchat,Salman T. Qureshi,Bruce Mazer,Karen L. Mossman,Danielle Malo,Ana M. Gamero,Silvia M. Vidal,Irah L. King,Marika Sarfati,Jörg H. Fritz +16 more
TL;DR: It is found that deficiency in signaling via type I interferon receptor led to deregulated activation of group 2 innate lymphoid cells (ILC2 cells) and infection-associated type 2 immunopathology.
Journal ArticleDOI
Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis.
TL;DR: Interestingly, ILC2, despite their scarcity, are the dominant innate lymphoid cell population in the lung, indicating a key role as first responders and amplifiers upon immune challenge at this site.
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IL-33 Signaling Regulates Innate and Adaptive Immunity to Cryptococcus neoformans
Adam Flaczyk,Claudia U. Duerr,Mitra Shourian,Erin I. Lafferty,Jörg H. Fritz,Salman T. Qureshi +5 more
TL;DR: It is demonstrated that IL-33–dependent signaling contributes to the expansion of innate type 2 immunity and subsequent Th2-biased lung immunopathology that facilitates C. neoformans growth and dissemination.
Journal ArticleDOI
Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia
Sasha Silva-Barrios,Mélina Smans,Claudia U. Duerr,Salman T. Qureshi,Jörg H. Fritz,Albert Descoteaux,Simona Stäger +6 more
TL;DR: Cell-specific ablation of endosomal TLR signaling in B cells revealed that innate B cell activation by L. donovani is responsible for disease exacerbation through IL-10 and IFN-I production and for the promotion of hypergammaglobulinemia.
Journal ArticleDOI
Ubiquitin Specific Protease 21 Is Dispensable for Normal Development, Hematopoiesis and Lymphocyte Differentiation
Jaspreet Pannu,Jad I. Belle,Michael Förster,Claudia U. Duerr,Shiyang Shen,Leanne Kane,Katherine Harcourt,Jörg H. Fritz,Simon Clare,Anastasia Nijnik +9 more
TL;DR: The contrast in the phenotype of the Usp21-knockout mice strongly indicates that USP21 is redundant for the regulation of GATA3 and RIPK1 activity during mouse development, in hematopoietic stem cells, and in lymphocyte differentiation.