C
Claudio Derada Troletti
Publications - 1
Citations - 53
Claudio Derada Troletti is an academic researcher. The author has contributed to research in topics: Regulation of gene expression & PINK1. The author has an hindex of 1, co-authored 1 publications receiving 49 citations.
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A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity
Julien Dusonchet,Julien Dusonchet,Hu Li,Maria Guillily,Min Liu,Klodjan Stafa,Claudio Derada Troletti,Joon Y. Boon,Shamol Saha,Liliane Glauser,Adamantios Mamais,Allison Citro,Katherine L. Youmans,Li Qun Liu,Bernard L. Schneider,Patrick Aebischer,Zhenyu Yue,Rina Bandopadhyay,Marcie A. Glicksman,Darren J. Moore,James J. Collins,James J. Collins,Benjamin Wolozin +22 more
TL;DR: RGS2 is identified as a promising target for interfering with neurodegeneration due to LRRK2 mutations in PD patients and found that RGS2 regulates L RRK2 function and neuronal toxicity through its effects on kinase activity and independently of GTPase activity, which reveals a novel mode of action for GAP proteins.