M
Marcie A. Glicksman
Researcher at Brigham and Women's Hospital
Publications - 65
Citations - 2377
Marcie A. Glicksman is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Kinase & SMA*. The author has an hindex of 27, co-authored 64 publications receiving 2093 citations. Previous affiliations of Marcie A. Glicksman include Indiana University.
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Journal ArticleDOI
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.
Valerie Cullen,S. Pablo Sardi,Juliana Ng,You-Hai Xu,Ying Sun,Julianna J. Tomlinson,Piotr Kolodziej,Ilana Kahn,Paul Saftig,John Woulfe,Jean-Christophe Rochet,Marcie A. Glicksman,Seng H. Cheng,Gregory A. Grabowski,Lamya S. Shihabuddin,Michael G. Schlossmacher,Michael G. Schlossmacher +16 more
TL;DR: Mechanisms for the GBA1 gene's association with increased synucleinopathy risk are explored and a loss in lysosomal acid–β‐glucosidase enzyme activity underlies Gaucher disease.
Assay Guidance Manual
G. Sitta Sittampalam,Nathan P. Coussens,Henrike Nelson,Michelle R. Arkin,Douglas S. Auld,Christopher M. Austin,Bruce E. Bejcek,Marcie A. Glicksman,James Inglese,Philip W. Iversen,Zhuyin Li,James McGee,Owen B. McManus,Lisa Minor,Andrew D. Napper,John M. Peltier,Terry L. Riss,O. Joseph Trask,Jeffrey R. Weidner +18 more
TL;DR: This chapter contains guidelines to develop therapeutic hypotheses, target and pathway validation, proof of concept criteria and generalized cost analyses at various stages of early drug discovery.
Journal ArticleDOI
Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection
Qiongman Kong,Ling-Chu Chang,Kou Takahashi,Qibing Liu,Delanie A. Schulte,Liching Lai,Brian Ibabao,Yuchen Lin,Nathan Stouffer,Chitra Das Mukhopadhyay,Xuechao Xing,Kathleen Seyb,Gregory D. Cuny,Marcie A. Glicksman,Chien-Liang Glenn Lin +14 more
TL;DR: This study demonstrated that LDN/OSU-0212320 treatment results in activation of PKC and subsequent Y-box-binding protein 1 (YB-1) activation, which regulates activation of EAAT2 translation, which indicates that the use of small molecules to enhance EAat2 translation may be a therapeutic strategy for the treatment of neurodegenerative diseases.
Journal ArticleDOI
Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease
Jian Xu,Manavi Chatterjee,Tyler D. Baguley,Jonathan Brouillette,Pradeep Kurup,Debolina Ghosh,Jean Kanyo,Yang Zhang,Kathleen Seyb,Chimezie Ononenyi,Ethan Foscue,George M. Anderson,Jodi Gresack,Gregory D. Cuny,Marcie A. Glicksman,Paul Greengard,TuKiet T. Lam,Lutz Tautz,Angus C. Nairn,Jonathan A. Ellman,Paul J. Lombroso +20 more
TL;DR: An unusual sulfur-based chemical is identified as a novel and specific inhibitor of the tyrosine phosphatase STEP and it is shown that it can improve the cognitive function of a mouse model of Alzheimer's disease.
Journal ArticleDOI
Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease
Kou Takahashi,Qiongman Kong,Yuchen Lin,Nathan Stouffer,Delanie A. Schulte,Liching Lai,Qibing Liu,Ling-Chu Chang,Sky Dominguez,Xuechao Xing,Gregory D. Cuny,Gregory D. Cuny,Kevin J. Hodgetts,Marcie A. Glicksman,Chien-Liang Glenn Lin +14 more
TL;DR: It is demonstrated that restoring glial glutamate transporter EAAT2 function improves cognitive functions and synaptic integrity while reducing amyloid plaques in a sustained fashion after treatment cessation.