C
Claudio E. Perez-Leighton
Researcher at Pontifical Catholic University of Chile
Publications - 38
Citations - 699
Claudio E. Perez-Leighton is an academic researcher from Pontifical Catholic University of Chile. The author has contributed to research in topics: Orexin & Medicine. The author has an hindex of 14, co-authored 32 publications receiving 543 citations. Previous affiliations of Claudio E. Perez-Leighton include United States Department of Veterans Affairs & Andrés Bello National University.
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Journal ArticleDOI
Brain orexin promotes obesity resistance
Catherine M. Kotz,Catherine M. Kotz,Joshua P. Nixon,Joshua P. Nixon,Tammy A. Butterick,Tammy A. Butterick,Claudio E. Perez-Leighton,Claudio E. Perez-Leighton,Jennifer A. Teske,Charles J. Billington,Charles J. Billington +10 more
TL;DR: The hypothalamic neuropeptide orexin (hypocretin) may play a key role in regulating SPA and NEAT and greater activation of this SPA network leads to a lower propensity for fat mass gain and therefore may be an attractive target for obesity prevention and therapy.
Journal ArticleDOI
Inwardly rectifying potassium channel Kir4.1 is responsible for the native inward potassium conductance of satellite glial cells in sensory ganglia.
TL;DR: Findings in combination with previous reports support the notion that Kir4.1 is the principal Kir channel type in SGCs, and emerges as a key regulator of SGC function and possibly neuronal excitability in sensory ganglia.
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Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits.
TL;DR: It is shown that melanopsin‐evoked electrical responses largely persist in ipRGCs recorded from early postnatal and adult mice lacking expression of functional TRPC3, TRPC6 or TRPC7 subunits, and that the melanopigment signaling pathway includes TRPC4‐containing heteromeric channels in mature retinas.
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Behavioral responses to orexin, orexin receptor gene expression, and spontaneous physical activity contribute to individual sensitivity to obesity
Claudio E. Perez-Leighton,Kelsey Boland,Jennifer A. Teske,Jennifer A. Teske,Charles J. Billington,Catherine M. Kotz,Catherine M. Kotz +6 more
TL;DR: It is estimated that the energetic cost of SPA after orexin A RLH injection accounts for approximately 61% of the extra caloric intake associated with HF intake, suggesting additional effects of orexins.
Journal ArticleDOI
Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area.
Vijayakumar Mavanji,Claudio E. Perez-Leighton,Catherine M. Kotz,Catherine M. Kotz,Charles J. Billington,Charles J. Billington,Sairam Parthasarathy,Christopher M. Sinton,Jennifer A. Teske +8 more
TL;DR: Data show the ventrolateral preoptic area is a site of action for orexin-A, which may promote negative energy balance by modulating sleep/wakefulness and stimulating spontaneous physical activity and energy expenditure.