J
Joel Abramowitz
Researcher at National Institutes of Health
Publications - 36
Citations - 2608
Joel Abramowitz is an academic researcher from National Institutes of Health. The author has contributed to research in topics: TRPC & Transient receptor potential channel. The author has an hindex of 26, co-authored 36 publications receiving 2376 citations. Previous affiliations of Joel Abramowitz include Research Triangle Park.
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Journal ArticleDOI
TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination
Jana Hartmann,Elena Dragicevic,Helmuth Adelsberger,Horst A. Henning,Martin Sumser,Joel Abramowitz,Robert Blum,Alexander Dietrich,Marc Freichel,Veit Flockerzi,Lutz Birnbaumer,Arthur Konnerth +11 more
TL;DR: Taken together, the results establish TRPC3 as a new type of postsynaptic channel that mediates mGluR-dependent synaptic transmission in cerebellar Purkinje cells and is crucial for motor coordination.
Journal ArticleDOI
Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels
Yanhong Liao,Christian Erxleben,Joel Abramowitz,Veit Flockerzi,Michael X. Zhu,David L. Armstrong,Lutz Birnbaumer +6 more
TL;DR: It is proposed that SOCE/Icrac channels are composed of heteromeric complexes that include TRPCs and Orai proteins, and functional interaction between ROCE and SOCE components is shown.
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A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry
Yanhong Liao,Nicholas W. Plummer,Margaret D. George,Joel Abramowitz,Michael X. Zhu,Lutz Birnbaumer +5 more
TL;DR: It is shown that the R91W mutant also blocks diacylglycerol (DAG)-activated Ca2+ entry into cells that stably, or transiently, express DAG-responsive TRPC proteins, which strongly suggests that Orai and TR PC proteins form complexes that participate in Ca 2+ entry with or without activation of store depletion.
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TRPC1 Channels Are Critical for Hypertrophic Signaling in the Heart
Malini Seth,Zhu Shan Zhang,Lan Mao,Victoria Graham,Jarrett Burch,Jonathan A. Stiber,Leonidas Tsiokas,Michelle P. Winn,Joel Abramowitz,Howard A. Rockman,Lutz Birnbaumer,Paul B. Rosenberg +11 more
TL;DR: It is suggested that TRPC1 channels are critical for the adaptation to biomechanical stress and TRPC dysregulation leads to maladaptive cardiac hypertrophy and failure.
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TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells
Kathryn Quick,Jing Zhao,Niels Eijkelkamp,John E. Linley,Francois Rugiero,James J. Cox,Ramin Raouf,Martine Gringhuis,Jane E. Sexton,Joel Abramowitz,Ruth Taylor,Andrew Forge,Jonathan Ashmore,Nerissa K. Kirkwood,Corné J. Kros,Guy P. Richardson,Marc Freichel,Veit Flockerzi,Lutz Birnbaumer,John N. Wood,John N. Wood +20 more
TL;DR: Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells, and are potential components of mechanotransducing complexes.