C
Clémence Cheignon
Researcher at University of Strasbourg
Publications - 12
Citations - 1521
Clémence Cheignon is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Oxidative stress & Chemistry. The author has an hindex of 7, co-authored 9 publications receiving 972 citations. Previous affiliations of Clémence Cheignon include Centre national de la recherche scientifique & University of Toulouse.
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Journal ArticleDOI
Oxidative stress and the amyloid beta peptide in Alzheimer's disease.
Clémence Cheignon,M. Tomas,M. Tomas,Dominique Bonnefont-Rousselot,Peter Faller,Christelle Hureau,Christelle Hureau,Fabrice Collin,Fabrice Collin +8 more
TL;DR: This review highlights the existing link between oxidative stress and AD, and the consequences towards the Aβ peptide and surrounding molecules in terms of oxidative damage, along with the implication of metal ions in AD.
Journal ArticleDOI
Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease
Clémence Cheignon,Clémence Cheignon,Megan Jones,Elena Atrián-Blasco,Isabelle Kieffer,Peter Faller,Fabrice Collin,Fabrice Collin,Christelle Hureau +8 more
TL;DR: ROS production proceeds through a Cu–Aβ state in which Cu(i/ii) binds to the NH2 and COO– groups of Asp1 and a histidine.
Journal ArticleDOI
Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production
Clémence Cheignon,Clémence Cheignon,Peter Faller,Peter Faller,Denis Testemale,Denis Testemale,Christelle Hureau,Christelle Hureau,Fabrice Collin,Fabrice Collin +9 more
TL;DR: It is demonstrated that the oxidative damage undergone by Aβ during MCO lead to a change in copper coordination, with enhanced catalytic properties that increases the rates of ascorbate consumption and HO• production, and the amount of HO• released by the system.
Journal ArticleDOI
Oxidative stress as a biomarker for Alzheimer's disease.
Fabrice Collin,Fabrice Collin,Clémence Cheignon,Clémence Cheignon,Clémence Cheignon,Christelle Hureau,Christelle Hureau +6 more
TL;DR: Loosely bound metal ions (copper and iron), present in the brain and at high concentration in senile plaques of AD patients, may bind to the amyloid beta peptide (Aβ), thus catalyzing very efficiently the production of ROS (in particular, the oligomeric forms of Aβ, known as being the most toxic).
Journal ArticleDOI
Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?
Clémence Cheignon,Clémence Cheignon,Fabrice Collin,Fabrice Collin,Peter Faller,Peter Faller,Christelle Hureau,Christelle Hureau +7 more
TL;DR: Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer’s disease shows that a protective activity can only be observed at high asCorbate concentration for exogenous molecules but not for the amyloid-β peptide itself.