Clemente Dato

TL;DR: BDNF- treated R6/2 mice survived longer and displayed less severe signs of neurological dysfunction than the vehicle treated ones, and systemically administered BDNF increased the synthesis of BDNF as demonstrated by RT-PCR, and this might account for the beneficial effects observed in this model.

TL;DR: This study is among the largest screenings of consecutive HSP index cases enrolled in real-life clinical-diagnostic settings, and its results corroborate NGS as a modern, first-step procedure for molecular diagnosis of HSP.

TL;DR: It is demonstrated that PDE10A is increased in the spiny neurons of R6/2 mice striatum, which is likely to contribute to cell damage in HD by hydrolyzing greater amounts of cyclic nucleotides.

TL;DR: This study uncovers a novel pathway involved in AD progression that is inhibited by Verapamil, shedding new light on the understanding of the therapeutic potential of VerAPamil in AD.

TL;DR: The study confirms and extends the concept that the expression of phosphorylated ERK 1/2 is related to neuronal vulnerability and is implicated in the pathophysiology of cell death in HD.