C
Cleslei Fernando Zanelli
Researcher at Sao Paulo State University
Publications - 58
Citations - 1451
Cleslei Fernando Zanelli is an academic researcher from Sao Paulo State University. The author has contributed to research in topics: EIF5A & Hypusine. The author has an hindex of 17, co-authored 57 publications receiving 1234 citations. Previous affiliations of Cleslei Fernando Zanelli include University of São Paulo.
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Journal ArticleDOI
Functional significance of eIF5A and its hypusine modification in eukaryotes
TL;DR: EIF5A and the hypusine biosynthetic enzymes are novel potential targets for intervention in aberrant cell proliferation, in view of the extraordinary specificity and functional significance of Hypusine-containing eIF 5A in mammalian cell proliferation.
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eIF5A has a function in the elongation step of translation in yeast.
Ana Paula Borges Gregio,Veridiana P. S. Cano,Juliana S Avaca,Sandro Roberto Valentini,Cleslei Fernando Zanelli +4 more
TL;DR: It is demonstrated that the formation of P bodies is inhibited in an eIF5A mutant, similarly to the effect of the translation elongation inhibitor cycloheximide.
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eIF5A binds to translational machinery components and affects translation in yeast.
Cleslei Fernando Zanelli,Ana Leticia Maragno,Ana Paula Borges Gregio,Suzanne Komili,José Rodrigo C. Pandolfi,Carlos Alberto Mestriner,Wilton R. Lustri,Sandro Roberto Valentini +7 more
TL;DR: It is demonstrated that eIF-5A interacts with structural components of the 80S ribosome, as well as with the translation elongation factor 2 (eEF2).
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Is there a role for eIF5A in translation
TL;DR: The putative translation factor eIF5A is essential for cell viability and is highly conserved from archaebacteria to mammals and has also been implicated in nuclear export of HIV-1 Rev and mRNA decay, but these findings are controversial in the literature and may reflect secondary effects of eIF-5A function.
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Epigenetic silencing of CRABP2 and MX1 in head and neck tumors.
Marilia Freitas Calmon,Rodrigo V. Rodrigues,Carla Martins Kaneto,Ricardo P. Moura,Sabrina Daniela da Silva,Louise Danielle de Carvalho Mota,Daniel Guariz Pinheiro,Cesar Torres,Alex Fiorini de Carvalho,Patrícia Maluf Cury,Fábio Daumas Nunes,Inês Nobuko Nishimoto,Fernando Augusto Soares,Adriana Madeira Álvares da Silva,L.P. Kowalski,Helena Brentani,Cleslei Fernando Zanelli,Wilson A. Silva,Paula Rahal,Eloiza H. Tajara,Dirce Maria Carraro,Anamaria A. Camargo,Sandro Roberto Valentini +22 more
TL;DR: In this study, rapid subtractive hybridization and microarray analysis was combined to select genes that are putatively reactivated by the demethylating agent 5-aza-2'-deoxycytidine in HNSCC cell lines, supporting a potential use of CRABP2 expression as a prognostic biomarker for H NSCC patients.