K
Kazuhiro Nishimura
Researcher at Chiba University
Publications - 49
Citations - 2310
Kazuhiro Nishimura is an academic researcher from Chiba University. The author has contributed to research in topics: Spermine & Spermidine. The author has an hindex of 25, co-authored 49 publications receiving 2095 citations. Previous affiliations of Kazuhiro Nishimura include National Institutes of Health.
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Functional significance of eIF5A and its hypusine modification in eukaryotes
TL;DR: EIF5A and the hypusine biosynthetic enzymes are novel potential targets for intervention in aberrant cell proliferation, in view of the extraordinary specificity and functional significance of Hypusine-containing eIF 5A in mammalian cell proliferation.
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Decrease in polyamines with aging and their ingestion from food and drink.
TL;DR: The results suggest that maintenance of polyamine levels may play important roles in the function of the pancreas, brain and uterus in 3- to 26-week-old mice and offer useful information when it becomes necessary to ingest polyamines from food.
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Polyamine Oxidase and Acrolein as Novel Biochemical Markers for Diagnosis of Cerebral Stroke
Hideyuki Tomitori,Teruyoshi Usui,Naokatsu Saeki,Shiro Ueda,Hiroshi Kase,Kazuhiro Nishimura,Keiko Kashiwagi,Kazuei Igarashi +7 more
TL;DR: The results indicate that increased levels of AcPAO, SMO, and acrolein are good markers of stroke.
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Independent roles of eIF5A and polyamines in cell proliferation.
Kazuhiro Nishimura,Kaori Murozumi,Akira Shirahata,Myung Hee Park,Keiko Kashiwagi,Kazuei Igarashi +5 more
TL;DR: Results show that a decrease in either active eIF5A or polyamines inhibits cell growth, indicating that eif5A and polyamines are independently involved in cell growth.
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Essential role of S‐adenosylmethionine decarboxylase in mouse embryonic development
Kazuhiro Nishimura,Fubito Nakatsu,Fubito Nakatsu,Keiko Kashiwagi,Hiroshi Ohno,Takashi Saito,Kazuei Igarashi +6 more
TL;DR: To examine the role of polyamines in embryogenesis, targeted disruption of the mouse Amd1 gene, encoding AdoMetDC, was carried out to generate mice that can not synthesize spermidine and spermine.