C
Cliff R. Stevens
Researcher at University of Bath
Publications - 26
Citations - 1682
Cliff R. Stevens is an academic researcher from University of Bath. The author has contributed to research in topics: Xanthine oxidase & Nitric oxide. The author has an hindex of 15, co-authored 26 publications receiving 1600 citations. Previous affiliations of Cliff R. Stevens include Royal National Hospital for Rheumatic Diseases & University of London.
Papers
More filters
Journal ArticleDOI
Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions
Timothy M. Millar,Cliff R. Stevens,Nigel Benjamin,Robert Eisenthal,Roger Harrison,David R. Blake +5 more
TL;DR: These enzymic reactions provide a mechanism for generation of NO under hypoxic conditions where nitric oxide synthase does not function, suggesting a vasodilatory role in ischaemia.
Journal ArticleDOI
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase.
Ben L.J. Godber,Justin J. Doel,Gopal P. Sapkota,David R. Blake,Cliff R. Stevens,Robert Eisenthal,Roger Harrison +6 more
TL;DR: Xanthine oxidase was shown to catalyze the reduction of nitrite to nitric oxide (NO) in the presence of either NADH or xanthine as reducing substrate, and it is proposed that XO-derived NO fulfills a bactericidal role in the digestive tract.
Journal ArticleDOI
Porcine collagen crosslinking, degradation and its capability for fibroblast adhesion and proliferation.
Marcus Jarman-Smith,Tulin Bodamyali,Cliff R. Stevens,John A. Howell,Michael Horrocks,Julian B. Chaudhuri +5 more
TL;DR: Porcine dermal collagen permanently crosslinked with hexamethylene diisocyanate was investigated for its suitability as a dermal tissue engineering matrix and found that the chemically crosslinked collagen had far fewer free lysine groups per collagen molecule than did the uncrosslinked matrix.
Journal ArticleDOI
A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury: the role of NADH as an electron donor.
Zhi Zhang,D R Blake,Cliff R. Stevens,Janos M. Kanczler,Paul G. Winyard,Martyn C.R. Symons,Mustapha Benboubetra,Roger Harrison +7 more
TL;DR: It is concluded that both human xanthine dehydrogenase (XD) and XO can oxidise NADH to generate ROS, and the conversion of XD to XO is not necessary for post-ischaemic ROS generation.