G
Gopal P. Sapkota
Researcher at University of Dundee
Publications - 69
Citations - 5822
Gopal P. Sapkota is an academic researcher from University of Dundee. The author has contributed to research in topics: Phosphorylation & Kinase. The author has an hindex of 31, co-authored 66 publications receiving 5292 citations. Previous affiliations of Gopal P. Sapkota include Medical Research Council & University of Bath.
Papers
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Journal ArticleDOI
Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
Claudio Alarcón,Alexia Ileana Zaromytidou,Qiaoran Xi,Sheng Gao,Jianzhong Yu,Sho Fujisawa,Afsar Barlas,Alexandria N. Miller,Katia Manova-Todorova,Maria J. Macias,Gopal P. Sapkota,Duojia Pan,Duojia Pan,Joan Massagué,Joan Massagué +14 more
TL;DR: A subsequent agonist-induced phosphorylation that plays a central dual role in Smad transcriptional activation and turnover is identified that is an integral part of canonical BMP and TGF-beta pathways.
Journal ArticleDOI
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase.
Ben L.J. Godber,Justin J. Doel,Gopal P. Sapkota,David R. Blake,Cliff R. Stevens,Robert Eisenthal,Roger Harrison +6 more
TL;DR: Xanthine oxidase was shown to catalyze the reduction of nitrite to nitric oxide (NO) in the presence of either NADH or xanthine as reducing substrate, and it is proposed that XO-derived NO fulfills a bactericidal role in the digestive tract.
Journal ArticleDOI
Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker
TL;DR: It is shown that linker phosphorylation restricts Smad1 activity by enabling Smad2 recognition by the HECT-domain ubiquitin ligase Smurf1, and the interplay between linkerosphorylation, Smirf-dependent ubiquitination, and nucleoporin exclusion enables regulation of BMP action by diverse signals and biological contexts.
Journal ArticleDOI
Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD
Annette F. Baas,Jérôme Boudeau,Gopal P. Sapkota,Linda Smit,René H. Medema,Nick A. Morrice,Dario R. Alessi,Hans Clevers +7 more
TL;DR: In this paper, the identification and characterization of an LKB1-specific adaptor protein and substrate, STRAD (STe20 Related ADaptor), has been reported.
Journal ArticleDOI
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.
Sheng Gao,Claudio Alarcón,Gopal P. Sapkota,Sadia Rahman,Pan-Yu Chen,Nina Goerner,Maria J. Macias,Hediye Erdjument-Bromage,Paul Tempst,Joan Massagué +9 more
TL;DR: Previously identified as a regulator of renal sodium channels, Nedd4L is shown here to play a broader role as a general modulator of Smad turnover during TGF-beta signal transduction.