C
Clifford V. Harding
Researcher at Case Western Reserve University
Publications - 203
Citations - 22392
Clifford V. Harding is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Antigen & Antigen processing. The author has an hindex of 71, co-authored 201 publications receiving 20418 citations. Previous affiliations of Clifford V. Harding include University Hospitals of Cleveland & Washington University in St. Louis.
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Journal ArticleDOI
B lymphocytes secrete antigen-presenting vesicles.
Graça Raposo,Hans W. Nijman,Willem Stoorvogel,R Liejendekker,Clifford V. Harding,Cornelis J. M. Melief,Hans J. Geuze +6 more
TL;DR: It is demonstrated by immunoelectron microscopy that the limiting membrane of MIICs can fuse directly with the plasma membrane, resulting in release from the cells of internal MHC class II-containing vesicles, suggesting a role for exosomes in antigen presentation in vivo.
Journal ArticleDOI
Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
TL;DR: The data suggest that transferrin is internalized via coated pits and vesicles and demonstrate thatTransferrin and its receptor are recycled back to the plasma membrane after endocytosis, and are shown to be lysosomal in nature.
Journal ArticleDOI
CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.
TL;DR: CpG ODN provide a signal to switch on Th1-dominated responses to coadministered antigen and are potential adjuvants for human vaccines to elicit protective Th1 immunity.
Journal ArticleDOI
Receptor-mediated endocytosis.
Journal ArticleDOI
Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
John D. Pfeifer,Mary Jo Wick,Richard L. Roberts,Kirk Findlay,Staffan Normark,Clifford V. Harding +5 more
TL;DR: It is reported here that phagocytosis of bacteria with no mechanism for cytosolic penetration also results in presentation of bacterial antigens by class I MHC molecules, and this mechanism is resistant to cycloheximide and Brefeldin A, which block the classical class I processing pathway.