C
Clyde W. Hodge
Researcher at University of North Carolina at Chapel Hill
Publications - 103
Citations - 7898
Clyde W. Hodge is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Nucleus accumbens & GABAA receptor. The author has an hindex of 47, co-authored 99 publications receiving 7529 citations. Previous affiliations of Clyde W. Hodge include Wake Forest University & University of Washington.
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Journal ArticleDOI
Adolescent cortical development : A critical period of vulnerability for addiction
TL;DR: Findings supporting adolescence as a critical period of cortical development important for establishing life long adult characteristics that are disrupted by alcohol and drug use are presented.
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A novel nociceptor signaling pathway revealed in protein kinase c ε mutant mice
Sachia G. Khasar,Yu Huei Lin,Annick Martin,Jahan Dadgar,Thomas A. McMahon,Dan Wang,Bhupinder Hundle,K. O. Aley,William M. Isenberg,Gordon C McCarter,Paul G. Green,Clyde W. Hodge,Jon D. Levine,Robert O. Messing +13 more
TL;DR: It is shown that epinephrine-induced mechanical and thermal hyperalgesia and acetic acid–associated hyperalGESia are markedly attenuated in PKCe mutant mice, but baseline nociceptive thresholds are normal, suggesting that PKCE inhibitors could prove useful in the treatment of pain.
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Supersensitivity to allosteric GABA A receptor modulators and alcohol in mice lacking PKCε
Clyde W. Hodge,Kristin K. Mehmert,Stephen P. Kelley,Thomas A. McMahon,Ashley Haywood,M. Foster Olive,Dan Wang,Ana María Sánchez-Pérez,Robert O. Messing +8 more
TL;DR: It is demonstrated that mutant mice lacking protein kinase C epsilon (PKCε) were more sensitive than wild-type littermates to the acute behavioral effects of ethanol and other drugs that allosterically activate GABAA receptors.
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Stimulation of Endorphin Neurotransmission in the Nucleus Accumbens by Ethanol, Cocaine, and Amphetamine
TL;DR: It is hypothesize that this drug-induced release of endorphins may contribute to the positive reinforcing and motivating properties of ethanol and psychostimulants.
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Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake.
TL;DR: It is demonstrated that extracellular CRF levels are increased in the BNST during ethanol withdrawal, and that these increases are reduced by subsequent ethanol intake.