Colin D. Chapman

TL;DR: Molecular mechanisms potentially underlying the memory-enhancing and neuroprotective effects of intranasal insulin are presented and an overview of neuroimaging studies indicating that disturbances in insulin metabolism and altered brain responses to insulin are linked to decreased cerebral volume and especially to hippocampal atrophy is provided.

TL;DR: In this paper, the intranasal delivery is proposed as a noninvasive option for delivering drugs to the central nervous system (CNS) with minimal peripheral exposure, which facilitates the delivery of large and/or charged therapeutics which fail to effectively cross the blood-brain barrier (BBB).

TL;DR: The results suggest that overeating in the morning after sleep loss is driven by both homeostatic and hedonic factors, and show that portion size choice afterSleep loss depend on both an individual's hunger status, and the type of food offered.

TL;DR: A narrative review of existing epidemiological findings, experimental work, and most importantly putative molecular and behavioral mechanisms connecting excessive sleep duration with both obesity and type 2 diabetes mellitus addresses recent findings suggesting a worrisome bidirectional effect such that metabolic disorders create a positive feedback loop which further perpetuates excessive sleep.

TL;DR: The results suggest that television watching, alcohol intake, and sleep deprivation are not merely correlated with obesity but likely contribute to it by encouraging excessive eating.