C
Colleen C. Nelson
Researcher at Queensland University of Technology
Publications - 273
Citations - 13932
Colleen C. Nelson is an academic researcher from Queensland University of Technology. The author has contributed to research in topics: Prostate cancer & LNCaP. The author has an hindex of 59, co-authored 265 publications receiving 12815 citations. Previous affiliations of Colleen C. Nelson include Princess Alexandra Hospital & University of British Columbia.
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Journal ArticleDOI
Androgen Levels Increase by Intratumoral De novo Steroidogenesis during Progression of Castration-Resistant Prostate Cancer
Jennifer A. Locke,Emma S. Tomlinson Guns,Amy A. Lubik,Hans Adomat,Stephen C. Hendy,Catherine A. Wood,Susan Ettinger,Martin E. Gleave,Colleen C. Nelson +8 more
TL;DR: In this article, the authors show that all enzymes necessary for androgen synthesis are expressed in prostate cancer tumors and some seem to be up-regulated during prostate cancer progression, leading to AR activation.
Journal ArticleDOI
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer.
Elahe A. Mostaghel,Stephanie T. Page,Daniel W. Lin,Ladan Fazli,Ilsa Coleman,Lawrence D. True,Beatrice S. Knudsen,David L. Hess,Colleen C. Nelson,Alvin M. Matsumoto,William J. Bremner,Martin E. Gleave,Peter S. Nelson,Peter S. Nelson +13 more
TL;DR: Optimal clinical efficacy will require testing of novel approaches targeting complete suppression of systemic and intracrine contributions to the prostatic androgen microenvironment.
Journal ArticleDOI
Interaction of Nuclear Receptors with the Wnt/β-Catenin/Tcf Signaling Axis: Wnt You Like to Know?
TL;DR: This review will focus on the cross-regulation of AR and Wnt/beta-catenin/Tcf but will also consider the dynamic manner in which RAR/RXR, GR, TR, VDR, ER, and PPAR modulate canonical Wnt signaling.
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Development and Application of a Salmonid EST Database and cDNA Microarray: Data Mining and Interspecific Hybridization Characteristics
Matthew L. Rise,Kristian R. von Schalburg,Gordon D. Brown,Melanie A. Mawer,Robert H. Devlin,Nathanael Kuipers,Maura Busby,Marianne Beetz-Sargent,Roberto Alberto,A. Ross Gibbs,Peter Hunt,Robert Shukin,Jeffrey A. Zeznik,Colleen C. Nelson,Simon R. M. Jones,Duane E. Smailus,Steven J.M. Jones,Jacqueline E. Schein,Marco A. Marra,Yaron S.N. Butterfield,Jeff M. Stott,Siemon H. S. Ng,William S. Davidson,Ben F. Koop +23 more
TL;DR: Higher- and lower-molecular-weight fractions of libraries are shown to contain distinct gene sets, and higher rates of gene discovery are associated with higher- molecular weight libraries.
Journal ArticleDOI
Dysregulation of Sterol Response Element-Binding Proteins and Downstream Effectors in Prostate Cancer during Progression to Androgen Independence
Susan Ettinger,Richard Sobel,Tanis G. Whitmore,Majid Akbari,Dawn R. Bradley,Martin E. Gleave,Colleen C. Nelson +6 more
TL;DR: The LNCaP xenograft model of human prostate cancer as well as clinical specimens of prostate cancer demonstrated an up-regulation of SREBPs and their downstream effector genes during progression to androgen independence.