E
Emma S. Tomlinson Guns
Researcher at Vancouver General Hospital
Publications - 87
Citations - 4148
Emma S. Tomlinson Guns is an academic researcher from Vancouver General Hospital. The author has contributed to research in topics: Prostate cancer & LNCaP. The author has an hindex of 30, co-authored 84 publications receiving 3622 citations. Previous affiliations of Emma S. Tomlinson Guns include Vancouver Prostate Centre & University of British Columbia.
Papers
More filters
Journal ArticleDOI
Androgen Levels Increase by Intratumoral De novo Steroidogenesis during Progression of Castration-Resistant Prostate Cancer
Jennifer A. Locke,Emma S. Tomlinson Guns,Amy A. Lubik,Hans Adomat,Stephen C. Hendy,Catherine A. Wood,Susan Ettinger,Martin E. Gleave,Colleen C. Nelson +8 more
TL;DR: In this article, the authors show that all enzymes necessary for androgen synthesis are expressed in prostate cancer tumors and some seem to be up-regulated during prostate cancer progression, leading to AR activation.
Journal ArticleDOI
Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy
Xia Li,Alexander L. Corbett,Erfan Taatizadeh,Nishat Tasnim,Jonathan P. Little,Cathie Garnis,Mads Daugaard,Emma S. Tomlinson Guns,Mina Hoorfar,Isaac T. S. Li +9 more
TL;DR: The current knowledge in exosome biogenesis, their roles in disease progression, and therapeutic applications and opportunities in bioengineering are summarized and the established and emerging technological developments inExosome isolation and characterization are highlighted.
Journal ArticleDOI
Exosomes as Biomarker Enriched Microvesicles: Characterization of Exosomal Proteins Derived from a Panel of Prostate Cell Lines with Distinct AR Phenotypes
TL;DR: This work characterized constitutive lipids, cholesterol and proteins from exosomes derived from six prostate cell lines and tracked their uptake in both cancerous and benign prostate cell Lines respectively, to provide insight for future work on both biomarker and therapeutic targets for the treatment of prostate cancer.
Journal Article
Discovery and Characterization of OC144-093, a Novel Inhibitor of P-Glycoprotein-mediated Multidrug Resistance
Michael J. Newman,Jennifer C. Rodarte,Khalid Benbatoul,Suzanne J. Romano,Chengzhi Zhang,Sonja Krane,Edmund J. Moran,Roy Teruyuki Uyeda,Ross Dixon,Emma S. Tomlinson Guns,Lawrence D. Mayer +10 more
TL;DR: The results demonstrate that OC144-093 is an orally active, potent, and nontoxic inhibitor of P-gp-mediated multidrug resistance that exhibits all of the desired properties for treatment and prevention of MDR prior to selection and/or induction of refractory disease.
Journal ArticleDOI
Reproducibility and efficiency of serum-derived exosome extraction methods.
Josselin Caradec,Geetanjali Kharmate,Elham Hosseini-Beheshti,Hans Adomat,Martin E. Gleave,Emma S. Tomlinson Guns +5 more
TL;DR: ExoQuick™ is an efficient and reproducible method to isolate exosomes for quantitative studies, whereas ultracentrifugation is not, but high albumin contamination of ultracentRifuged-derived exosome impairs the use of protein concentration as a mean to quantify serum-derivedExosomes.