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Concetta T. Ammollo
Researcher at University of Bari
Publications - 30
Citations - 3303
Concetta T. Ammollo is an academic researcher from University of Bari. The author has contributed to research in topics: Fibrinolysis & Thrombin. The author has an hindex of 15, co-authored 29 publications receiving 2701 citations. Previous affiliations of Concetta T. Ammollo include Oklahoma Medical Research Foundation.
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Journal ArticleDOI
Extracellular histones are major mediators of death in sepsis
Jun Xu,Xiaomei Zhang,Rosana Pelayo,Marc Monestier,Concetta T. Ammollo,Fabrizio Semeraro,Fletcher B. Taylor,Naomi L. Esmon,Florea Lupu,Charles T. Esmon,Charles T. Esmon +10 more
TL;DR: It is concluded that extracellular histones are potential molecular targets for therapeutics for sepsis and other inflammatory diseases.
Journal ArticleDOI
Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4
Fabrizio Semeraro,Concetta T. Ammollo,James H. Morrissey,George L. Dale,Paul Friese,Naomi L. Esmon,Charles T. Esmon +6 more
TL;DR: Data show that histone-activated platelets possess a procoagulant phenotype that drives plasma thrombin generation and suggest that TLR2 and TLR4 mediate the activation process.
Journal ArticleDOI
Extracellular histones increase plasma thrombin generation by impairing thrombomodulin‐dependent protein C activation
Concetta T. Ammollo,Fabrizio Semeraro,Jiaqiong Xu,Naomi L. Esmon,Naomi L. Esmon,Charles T. Esmon +5 more
TL;DR: From neutrophil extracellular traps release to thrombosis: an overshooting host‐defense mechanism?
Journal ArticleDOI
Sepsis, thrombosis and organ dysfunction.
TL;DR: New insights into the pathogenesis of DIC and MODS may have implications for the development of new therapeutic agents potentially useful for the management of severe sepsis.
Journal ArticleDOI
Sepsis-Associated Disseminated Intravascular Coagulation and Thromboembolic Disease
TL;DR: New insights into the pathogenetic mechanisms of DIC and MODS may have important implications for the development of new therapeutic agents that could be potentially useful particularly for the management of severe sepsis.