Cong Chen

TL;DR: The current knowledge and concepts concerning the exosomes involvement in breast cancer pathogenesis (including tumor initiation, invasion and metastasis, angiogenesis, immune system modulation and tumor microenvironment) and cancer therapy resistance are outlined.

TL;DR: It is demonstrated that H19 induces autophagy activation via the H19/SAHH/DNMT3B axis, which could contribute to tamoxifen resistance in breast cancer.

TL;DR: Overexpression of GLUT1 was found to significantly correlate with poor 3-year OS and 5-year survival in most solid tumors, suggesting that the expression status ofGLUT1 is a vital prognostic indicator and promising therapeutic target in solid tumors.

TL;DR: This study is the first to demonstrate that the ability of metformin to induce ferroptosis may be a novel mechanism underlying its anti-cancer effect, and identified SLC7A11 as a new UFMylation substrate and found that targeting the UFM1/SLC 7A11 pathway could be a promising cancer treatment strategy.

TL;DR: It is proposed that viewing ferroPTosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer.