다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

Recent developments in biological activities of chalcones: a mini review.

Recent advance in oxazole-based medicinal chemistry.

An insight on medicinal attributes of 1,2,4-triazoles.

Introduction: Chalcones are one of the major classes of naturally occurring compounds. A large number of synthetic routes have been reported for the synthesis of chalcones, the most classical and general being the Claisen–Schmidt condensation. Chalcones and their derivatives have a huge importance in medicinal chemistry, displaying a wide range of important pharmacological activities.Areas covered: The authors provide an overview of the recent scientific reports describing the obtention and study of new chalcones. The review emphasizes the rationale behind the natural sources, the discovery, the design, the synthesis, the biological activities and the study of structure–activity relationships of the new chalcone derivatives. The article is based on the literature published from June 2011 – 2014 related to the development of this family of compounds. The patents presented in this review have been collected from multiple electronic databases including Scifinder, Espacenet and Mendeley.Expert opinion: Althou...

Potential pharmacological uses of chalcones: a patent review (from June 2011 – 2014)

Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin.

In the title mol­ecule, C17H11F2N3O, the triazole ring makes dihedral angles of 83.00 (5) and 16.63 (5)°, respectively, with the phenyl and benzene rings. Weak inter­molecular C—H⋯F and C—H⋯N inter­actions contribute to the crystal packing.

https://journals.iucr.org/e/issues/2009/08/00/cv2596/cv2596.pdf

(Z)-1-(2,4-Difluoro­phen­yl)-3-phenyl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

In the title mol­ecule, C21H19FN4O, the triazole ring forms dihedral angles of 67.0 (1) and 59.6 (1)° with the phenyl and fluoro-substituted benzene rings, respectively. The dihedral angle between the phenyl ring and the fluoro-substituted benzene ring is 79.1 (1)°. The pyrrolidine ring is in a half-chair conformation. In the crystal, weak C—H⋯O and C—H⋯N hydrogen bonds connect mol­ecules into layers parallel to (001).

https://journals.iucr.org/e/issues/2012/06/00/lh5432/lh5432.pdf

Cong-Yan Yan

Papers

Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin.

(Z)-1-(2,4-Difluorophenyl)-3-phenyl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

(Z)-1-[4-Fluoro-2-(pyrrolidin-1-yl)phen-yl]-3-phenyl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one.

Cong-Yan Yan

Papers

Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin.

(Z)-1-(2,4-Difluoro­phen­yl)-3-phenyl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

(Z)-1-[4-Fluoro-2-(pyrrolidin-1-yl)phen-yl]-3-phenyl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one.

(Z)-1-(2,4-Difluorophenyl)-3-phenyl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one