Journal ArticleDOI
Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin.
Ben-Tao Yin,Cong-Yan Yan,Xin-Mei Peng,Shao-Lin Zhang,Syed Rasheed,Rong-Xia Geng,Cheng-He Zhou +6 more
TLDR
Compound 9a could effectively intercalate into Calf Thymus DNA to form 9a-DNA complex which might block DNA replication to exert their powerful antimicrobial activities, thus improving its antimicrobial efficacy.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2014-01-07. It has received 118 citations till now. The article focuses on the topics: Human serum albumin & Antimicrobial.read more
Citations
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Recent developments in biological activities of chalcones: a mini review.
TL;DR: This review article focuses on the recent developments (2010-2014) on various pharmacological and medicinal aspects of chalcones and their analogues.
Journal ArticleDOI
Recent advance in oxazole-based medicinal chemistry.
TL;DR: This work systematically reviewed the recent researches and developments of the whole range of oxazole compounds as medicinal drugs, including antibacterial, antifungal, antiviral, antitubercular, anticancer, anti-inflammatory and analgesic, antidiabetic, antiparasitic, anti -obesitic,Anti-neuropathic, antioxidative as well as other biological activities.
Journal ArticleDOI
An insight on medicinal attributes of 1,2,4-triazoles.
TL;DR: The pharmacological profile of 1,2,4-triazole, one of the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant, antituberculosis, antiviral, antiparasitic, analgesic and anti-inflammatory agents, etc. is summarized.
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Potential pharmacological uses of chalcones: a patent review (from June 2011 – 2014)
TL;DR: The review emphasizes the rationale behind the natural sources, the discovery, the design, the synthesis, the biological activities and the study of structure–activity relationships of the new chalcone derivatives.
References
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Book
Principles of fluorescence spectroscopy
TL;DR: This book describes the fundamental aspects of fluorescence, the biochemical applications of this methodology, and the instrumentation used in fluorescence spectroscopy.
Journal ArticleDOI
The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
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Thermodynamics of protein association reactions: forces contributing to stability
Philip D. Ross,S. Subramanian +1 more
TL;DR: On the basis of the thermochemical behavior of small molecule interactions, it is concluded that the strengthening of hydrogen bonds in the past decade, a complete thermodynamic description of the self-association of many proteins and their interactions is concluded.
Journal ArticleDOI
Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.
TL;DR: The results of the model compound study provide evidence for a mechanism that follows the classical Stern-Volmer law (1919), predominantly involving collisional quenching, and illustrate the importance of local charge and solvent viscosity.