C
Connie A. Myers
Researcher at Washington University in St. Louis
Publications - 28
Citations - 1930
Connie A. Myers is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Gene & Enhancer. The author has an hindex of 17, co-authored 28 publications receiving 1728 citations. Previous affiliations of Connie A. Myers include Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
Complex effects of nucleotide variants in a mammalian cis-regulatory element
TL;DR: It is concluded that some mammalian CREs are finely tuned by evolution and function through complex, nonadditive interactions between bound TFs, and CRE-seq will be an important tool to uncover the rules that govern these interactions.
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Massively parallel in vivo enhancer assay reveals that highly local features determine the cis-regulatory function of ChIP-seq peaks
TL;DR: It is found that very short sequences bound in the genome by Crx activated transcription at high levels, whereas unbound genomic regions with equal numbers of Crx motifs did not activate above background levels, even when liberated from their larger genomic context.
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From laminin to lamin: regulation of tissue-specific gene expression by the ECM
TL;DR: It is proposed that ECM-induced structural changes in the cytoskeleton, histone organization and the nuclear matrix contribute to this tissue-specific gene expression.
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A human breast cell model of preinvasive to invasive transition.
Aylin Rizki,Aylin Rizki,Valerie M. Weaver,Sun-Young Lee,Gabriela I. Rozenberg,Koei Chin,Connie A. Myers,Connie A. Myers,Jamie L. Bascom,Joni D. Mott,Jeremy R. Semeiks,Leslie Grate,Leslie Grate,I. Saira Mian,Alexander D. Borowsky,Roy A. Jensen,Michael O. Idowu,Fanqing Chen,David J. Chen,David J. Chen,Ole W. Petersen,Joe W. Gray,Joe W. Gray,Mina J. Bissell +23 more
TL;DR: This model provides a new tool for dissection of mechanisms by which preinvasive breast cells could acquire invasiveness in a metaplastic context.
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Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment.
Nancy Boudreau,Connie A. Myers +1 more
TL;DR: The contribution of the microenvironment to tumor-induced angiogenesis is underscored by findings that breast tumors implanted into different tissue sites show marked differences in the extent and nature of the angiogenic response.