Constantin Ştefani

TL;DR: In this paper, the authors present a review of breast cancer, the components of the AKT signaling pathway, the factors that activate this protein kinase B, PI3K/AKT-breast cancer mutations, PI 3k/AKt/mTOR-inhibitors, and the relationship between everolimus, temsirolimus and endocrine therapy.

TL;DR: In this article, the authors present the CRC incidence, risk factors, pathogenesis, and the impact of GFs during its development, and describe the relationship between EGF, IGF, VEGF, GFs inhibitors, PI3K/AKT/mTOR-MAPK signaling pathways, and CRC.

TL;DR: In this paper, drugs targeting the PI3K/AKT/mTOR signalling pathway may be one of the best therapeutic options for RCC, and Temsirolimus and everolimus are two mTOR inhibitors are currently used for the treatment of RCC.

TL;DR: In this article, increased visceral adipose tissue leads to renal glomerular hyperfiltration and hyperperfusion, which may lead to renal hypertrophy, proteinuria, and CKD development.

TL;DR: The main aim of this review is to present PC incidence, risk factors, tumor microenvironment development, and PI3K/AKT/mTOR dysregulation and inhibitors used in clinical, in vivo, and in vitro studies.