2.5. Ionic Liquids Presented in This Review 2020 3. Cyclocondensation Reactions 2020 4. Synthesis of Three-Membered Heterocycles 2022 4.1. Aziridines 2022 5. Synthesis of Five-Membered Heterocycles 2022 5.1. Pyrroles 2022 5.2. Furans 2022 5.3. Thiophenes 2023 5.4. Pyrazoles 2024 5.5. Imidazoles 2025 5.6. Isoxazoles 2027 5.7. Oxazoles, Oxazolines, and Oxazolidinones 2027 5.8. Thiazoles and Thiazolidinones 2028 6. Synthesis of Six-Membered Heterocycles 2030 6.1. Pyridines 2030 6.2. Quinolines 2031 6.3. Acridines 2033 6.4. Pyrans 2033 6.5. Flavones 2035 6.6. Pyrimidines and Pyrimidinones 2035 6.7. Quinazolines 2037 6.8. -Carbolines 2038 6.9. Dioxanes 2039 6.10. Oxazines 2039 6.11. Benzothiazines 2040 6.12. Triazines 2040 7. Synthesis of Seven-Membered Heterocycles: Diazepines 2041

Ionic liquids in heterocyclic synthesis.

The therapeutic journey of benzimidazoles: a review.

This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

/pdf/chromone-a-valid-scaffold-in-medicinal-chemistry-4qd4v5m5z2.pdf

Chromone: A Valid Scaffold in Medicinal Chemistry

o-Quinodimethanes: Efficient Intermediates in Organic Synthesis.

Coumarin heterocyclic derivatives: chemical synthesis and biological activity

3-Formylchromones react with zwitterionic intermediates, generated in situ from azodicarboxylates and PPh3, to afford the pyrazolines (III) and the novel class of tetrazepines.

Reactivity of the Mitsunobu Reagent Toward 3-Formylchromones: A Strategy for the One-Pot Synthesis of Chromeno[2,3-c]pyrazolines and Chromeno[2,3-e]tetrazepines.

SYNTHESIS 2009, No. 15, pp 2579–2583xx.xx.2009 Advanced online publication: 26.06.2009 DOI: 10.1055/s-0029-1216868; Art ID: P04009SS © Georg Thieme Verlag Stuttgart · New York Abstract: The regioselective one-pot synthesis of a new class of 4,6-dihydro[1,3]diazepino[5,6-b]indol-3(2H)-ones, in very good yields, via reaction of pyranoindolones with monosubstituted ureas is described. Reaction of N,N¢-disubstituted ureas with pyranoindolones, under similar conditions, gave the corresponding b-carbolinones. The reaction mechanisms leading to both types of product are discussed and the structures are confirmed by spectroscopic techniques.

A Versatile, Unexpected, One‐Pot Regioselective Synthesis of a New Class of 1,3‐Diazepinoindolones by Reaction of Pyranoindolones with Monosubstituted Ureas.

Reactions of O‐Methyl o‐Quinone Monoximes with Methyl‐, Methylene‐ and Methine‐Substituted Aromatic Compounds. Synthesis of Benzo[d]oxazole and 1,4‐Benzoxazine Derivatives.

The quinoxafino-2,3-quinodimethane was generated in situ from 2,3-bis(bromomethyl)-quinoxaline and was trapped with dienophiles to give 1:1 adducts. The Diels-Alder reactions were also examined on the basis of AM1 MO calculations.

Quinoxalino‐2,3‐quinodimethane: Formation of 1:1 Adducts with Dienophiles.

Treatment of 3-cyanochromones with the isocyanides (II) and acetylenecarboxylates in a molar ratio of 1:3:3 to results in formation of novel spirocyclic chromenes of type (IV) or (VI)/ (VIII).

Constantinos A. Tsoleridis

Papers

Reactivity of the Mitsunobu Reagent Toward 3-Formylchromones: A Strategy for the One-Pot Synthesis of Chromeno[2,3-c]pyrazolines and Chromeno[2,3-e]tetrazepines.

A Versatile, Unexpected, One‐Pot Regioselective Synthesis of a New Class of 1,3‐Diazepinoindolones by Reaction of Pyranoindolones with Monosubstituted Ureas.

Reactions of O‐Methyl o‐Quinone Monoximes with Methyl‐, Methylene‐ and Methine‐Substituted Aromatic Compounds. Synthesis of Benzo[d]oxazole and 1,4‐Benzoxazine Derivatives.

Quinoxalino‐2,3‐quinodimethane: Formation of 1:1 Adducts with Dienophiles.

One-Pot Five-Component Synthesis of Spirocyclopenta[b]chromene Derivatives and Their Acid-Catalyzed Rearrangement.