2.5. Ionic Liquids Presented in This Review 2020 3. Cyclocondensation Reactions 2020 4. Synthesis of Three-Membered Heterocycles 2022 4.1. Aziridines 2022 5. Synthesis of Five-Membered Heterocycles 2022 5.1. Pyrroles 2022 5.2. Furans 2022 5.3. Thiophenes 2023 5.4. Pyrazoles 2024 5.5. Imidazoles 2025 5.6. Isoxazoles 2027 5.7. Oxazoles, Oxazolines, and Oxazolidinones 2027 5.8. Thiazoles and Thiazolidinones 2028 6. Synthesis of Six-Membered Heterocycles 2030 6.1. Pyridines 2030 6.2. Quinolines 2031 6.3. Acridines 2033 6.4. Pyrans 2033 6.5. Flavones 2035 6.6. Pyrimidines and Pyrimidinones 2035 6.7. Quinazolines 2037 6.8. -Carbolines 2038 6.9. Dioxanes 2039 6.10. Oxazines 2039 6.11. Benzothiazines 2040 6.12. Triazines 2040 7. Synthesis of Seven-Membered Heterocycles: Diazepines 2041

Ionic liquids in heterocyclic synthesis.

The therapeutic journey of benzimidazoles: a review.

This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

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Chromone: A Valid Scaffold in Medicinal Chemistry

o-Quinodimethanes: Efficient Intermediates in Organic Synthesis.

Coumarin heterocyclic derivatives: chemical synthesis and biological activity

The synthesis of the title compounds and the evaluation of their in vitro cytogenic activity at typical concentration rates of the drug 1,4-benzodiazepine is presented.

One-Pot Microwave Assisted Synthesis of New 2-Alkoxycarbonylmethylene-4-oxo-1,5-benzo-, naphtho-, and pyridodiazepines and Assessment of Their Cytogenetic Activity.

Title compounds (IV) (11 examples) are obtained via a diastereo- and regioselective three-component, one-pot reaction.

Diastereoselective One‐Pot Synthesis of Novel ABCD‐Fused Chromeno[2,3‐d]pyrazolo[3,4‐b]pyridines.

The synthesis of a number of 2-anilino- and 2-(benzoylamino)-β -carbolin-3-ones in good yields by a one-step sequence from the reaction of pyranoindolones with phenylhydrazine or benzoylhydrazine is described; the observed good regioselectivity of the reaction is discussed. Full assignment of all 'H and 13 C NMR chemical shifts has been unambiguously achieved.

A Versatile One-Pot Synthesisof β-Carbolines by Reaction of Pyranoindolones with Phenyl-and Benzoylhydrazine

Methylisoquinoline-Based Three-Component Condensation Reactions Involving Chromone-3-carboxaldehydes: One-Pot Synthesis of a New Class of Chromenopyridoisoquinolines.

From the reaction of 2-acetylcyclopentanone with benzoylhydrazine, the cyclopentanopyrazole derivative 4 was obtained as the only product. The structural assignment of this compound and also of the hydroxypyrazoline 3, used as a model compound, was established by analysis of their NMR spectra (1H, 13C, COSY, NOESY, HETCOR and COLOC). Copyright © 2002 John Wiley & Sons, Ltd.

Constantinos A. Tsoleridis

Papers

One-Pot Microwave Assisted Synthesis of New 2-Alkoxycarbonylmethylene-4-oxo-1,5-benzo-, naphtho-, and pyridodiazepines and Assessment of Their Cytogenetic Activity.

Diastereoselective One‐Pot Synthesis of Novel ABCD‐Fused Chromeno[2,3‐d]pyrazolo[3,4‐b]pyridines.

A Versatile One-Pot Synthesisof β-Carbolines by Reaction of Pyranoindolones with Phenyl-and Benzoylhydrazine

Methylisoquinoline-Based Three-Component Condensation Reactions Involving Chromone-3-carboxaldehydes: One-Pot Synthesis of a New Class of Chromenopyridoisoquinolines.

Structure elucidation and conformational analysis of a fused cyclopentanopyrazolidinol