Cor Jf Fontes

TL;DR: Although the blood preserved as thick blood smears provides an alternative and useful tool for malaria molecular diagnosis, its relatively poor performance at low level parasitemias impairs the correct determination of malaria prevalence in epidemiological studies, but the results obtained confirm that the use of filter-paper to collect blood is useful for field studies.

TL;DR: Results presented here show that immunoglobulin GM allotypes contribute to the natural antibody responses to P. vivax malaria antigens, which have important implications for the effectiveness of vaccines containing PvAMA-1 or PvMSP1-19 antIGens.

TL;DR: It is demonstrated that activated as well as “atypical” memory B cells are expanded in peripheral blood of Pv-exposed individuals, but their frequencies were not associated with acute infection.

TL;DR: Evidence is provided that a persistent detection of EBV DNA in peripheral blood of adults in a P. vivax semi-immune population may impact the long-term immune response to major malaria vaccine candidates.

TL;DR: The presence of polymorphisms in the pvmdr-1 and pvcrt-o resistance genes of P. vivax in patients with better or worse prognosis is associated with clues of genetic indicators useful for assessing the virulence of the parasite and the prognosis of patients with v Vivax malaria.