C
Cornelia G van Helden-Meeuwsen
Researcher at Erasmus University Rotterdam
Publications - 36
Citations - 1480
Cornelia G van Helden-Meeuwsen is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Nod & Medicine. The author has an hindex of 20, co-authored 29 publications receiving 1208 citations.
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Journal ArticleDOI
Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression
Zana Brkic,Naomi I Maria,Cornelia G van Helden-Meeuwsen,Joop P. van de Merwe,Paul L A van Daele,Virgil A. S. H. Dalm,Manon E Wildenberg,Wouter Beumer,Hemmo A. Drexhage,Marjan A. Versnel +9 more
TL;DR: The monocyte IFN type I signature identifies a subgroup of patients with primary Sjögren's syndrome with a higher clinical disease activity together with higher BAFF mRNA expression.
Journal ArticleDOI
Systemic increase in type I interferon activity in Sjögren's syndrome: a putative role for plasmacytoid dendritic cells.
Manon E. Wildenberg,Cornelia G van Helden-Meeuwsen,Joop P. van de Merwe,Hemmo A. Drexhage,Marjan A. Versnel +4 more
TL;DR: It is indicated that the increased type I IFN activity observed in pSjS patients is not only a local but also a systemic phenomenon and points to pDC as a possible source of this activity.
Journal ArticleDOI
The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis
Zana Brkic,Lenny van Bon,Marta Cossu,Cornelia G van Helden-Meeuwsen,Madelon C. Vonk,Hanneke K. A. Knaapen,Wim B. van den Berg,Virgil A. S. H. Dalm,Paul L A van Daele,Adriana Severino,Naomi I Maria,Samara Guillen,Willem A. Dik,Lorenzo Beretta,Marjan A. Versnel,Timothy R D J Radstake +15 more
TL;DR: The presence of IFN type I signature in monocytes is correlated with BAFF mRNA expression and serum PIIINP levels, supporting a contribution in the pathogenesis and progression of SSc.
Journal ArticleDOI
MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjögren's syndrome
Naomi I Maria,Zana Brkic,Matti Waris,Cornelia G van Helden-Meeuwsen,Kim C. Heezen,Joop P. van de Merwe,Paul L A van Daele,Virgil A. S. H. Dalm,Hemmo A. Drexhage,Marjan A. Versnel +9 more
TL;DR: MxA levels associate with features of active disease and are reduced in hydroxychloroquine-treated patients, suggesting the clinical applicability of MxA in stratifying patients according to IFN positivity, and the MXA-EIA assays were excellent tools to assess IFN type I activity in pSS.
Journal ArticleDOI
Chorionic gonadotropin induces dendritic cells to express a tolerogenic phenotype
Hui Wan,Marjan A. Versnel,Lonneke M. Leijten,Cornelia G van Helden-Meeuwsen,Durk Fekkes,Pieter J. M. Leenen,Nisar Ahmed Khan,Robbert Benner,Rebecca C. M. Kiekens +8 more
TL;DR: Data are suggestive for a contribution of hCG to the maternal‐fetal tolerance during pregnancy by modifying dendritic cell (DC) function toward a tolerogenic phenotype.