W
Wim B. van den Berg
Researcher at Radboud University Nijmegen
Publications - 292
Citations - 24275
Wim B. van den Berg is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Arthritis & Inflammation. The author has an hindex of 84, co-authored 292 publications receiving 22530 citations. Previous affiliations of Wim B. van den Berg include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion.
Erik Lubberts,Marije I. Koenders,Birgitte Oppers-Walgreen,Liduine van den Bersselaar,Christina J. J. Coenen-de Roo,Leo A. B. Joosten,Wim B. van den Berg +6 more
TL;DR: IL-17 plays a role in early stages of arthritis, but also later during disease progression, and treatment with a neutralizing anti- IL-17 antibody after the onset of CIA significantly reduced the severity of CIA.
Journal ArticleDOI
Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFalpha, anti-IL-1alpha/beta and IL-1Ra.
TL;DR: The present study identified different TNF alpha/IL-1 dependencies in various stages of CIA and revealed that blocking of TNFalpha does not necessarily eliminate IL-1, and found that the IL- 1 beta isoform plays a dominant role in established CIA.
Journal ArticleDOI
The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
Rinke Stienstra,Leo A. B. Joosten,Tim B. Koenen,Berry van Tits,Janna A. van Diepen,Sjoerd A.A. van den Berg,Patrick C.N. Rensen,Peter J. Voshol,Giamilla Fantuzzi,Anneke Hijmans,Sander Kersten,Michael Müller,Wim B. van den Berg,Nico van Rooijen,Martin Wabitsch,Bart Jan Kullberg,Jos W. M. van der Meer,Thirumala D. Kanneganti,Cees J. Tack,Mihai G. Netea +19 more
TL;DR: The inflammasome is an important regulator of adipocyte function and insulin sensitivity, and caspase-1 inhibition may represent a novel therapeutic target in clinical conditions associated with obesity and insulin resistance.
Journal ArticleDOI
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
Shahla Abdollahi-Roodsaz,Leo A. B. Joosten,Marije I. Koenders,Isabel Devesa,Mieke F. Roelofs,Timothy R D J Radstake,Marleen Heuvelmans-Jacobs,Shizuo Akira,Martin J.H. Nicklin,Fátima Ribeiro-Dias,Wim B. van den Berg +10 more
TL;DR: It is shown that TLR2 and TLR4, but not TLR9, are involved in the pathogenesis of autoimmune arthritis and play distinct roles in the regulation of T cells and cytokines.
Journal ArticleDOI
IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis
Erik Lubberts,Leo A. B. Joosten,B Oppers,Liduine van den Bersselaar,Christina J. J. Coenen-de Roo,Jay K. Kolls,Paul Schwarzenberger,Fons A. J. van de Loo,Wim B. van den Berg +8 more
TL;DR: IL-17 is suggested to be a novel target for the treatment of destructive arthritis and may have implications for tissue destruction in other autoimmune diseases.