Cosimo Tortorella

TL;DR: Proinflammatory cytokine levels are increased in menstrual effluents of women with CE and a test dosing IL-6 and TNF-α seems to have a high screening capacity for CE.

TL;DR: The results indicate that the overall intrinsic mechanisms regulating neutrophil cell death are not affected by age, yet aged neutrophils showed a diminished capacity to be rescued by proinflammatory mediators, such as granulocyte–monocyte colony-stimulating factor, granulocytes colony- stimulating factor, and bacterial lipopolysaccharide, following Fas activation.

TL;DR: The data suggest the occurrence of an enhanced responsiveness to IL-10 modulating effects, likely mediated by an imbalance of IL-12 p40/p70 ratio, in chronic HCV infection and Cytokine balance restoration might thus contribute to achieve therapeutical results in chronic hepatitis C.

TL;DR: Serum samples from 60 patients with chronic hepatitis C displayed a significant immunoreactivity to crude plant extracts infected with the chimeric CMV, suggesting that further investigation should be made into a possible vaccine function for the CMV-HCV mimotope system.

TL;DR: An increased activity of inhibitory molecules, such as Src homology domain-containing protein tyrosine phosphatase-1 (SHP-1) and suppressors of cytokine signalling (SOCS), is responsible for the age-related failure of GM-CSF to stimulate neutrophil functions via inhibition of Lyn-, phosphoinositide 3-kinase (PI3-K)/extracellular signal-regulated kinase (ERK)- and signal transducers and