Showing papers in "Ageing Research Reviews in 2007"

TL;DR: The finding that the onset of human disc degeneration occurs as early as by adolescence is indicated, because they are the major causes of the biologic changes experienced by disc cells.

TL;DR: It is concluded that the informational websites offer helpful information for carers but seem less attuned to the person with dementia and do not offer personalized information.

TL;DR: The following question arises for the clinician: Why should soy or red clover products containing isoflavone be recommended, if the positive effects are only negligible but the adverse effects serious?

TL;DR: Key characteristics relating oxidative damage to aging and longevity are reviewed and both a low rate of generation of endogenous damage and an intrinsically high resistance to modification of tissue macromolecules are key traits of animal longevity.

TL;DR: The involvement of circadian proteins in the regulation of metabolism, genotoxic stress response and reactive oxygen species (ROS) homeostasis can be responsible for the premature aging, observed in some circadian mutants.

TL;DR: A historical perspective and critical evaluation of the model that CR acts through Sir2 in yeast, and how prior reports are interpreted in light of more recent discoveries is presented.

TL;DR: This review focuses on the pioneering research on novel delivery systems which can promote the therapeutic value of antioxidants for combating UV-induced photoageing.

TL;DR: Evidence from other species including yeast, nematodes, and flies suggest that evolutionarily well-conserved mechanisms are at play and the endocrine system is a key determinant on aging and longevity.

TL;DR: The results indicate that in natural fertility conditions longevity does not decrease when the number of children increases but, in modern populations, mortality could slightly increase when women have more than ca 5 children.

TL;DR: These fish are well suited for the investigation of basic processes implicated in aging, such as insulin signaling, oxidative stress, and comparative studies of species with widely divergent longevities.

TL;DR: Observations suggest that widely encountered premature aging-like features in klotho mutant mice are due to the inability of Fgf-23 to exert its bioactivities in absence of kloths, which will help to redefine the role of k lotho as an aging factor.

TL;DR: The similarities and differences in the pathology of neurodegeneration in PPID and PD are compared and the potential utility of the horse as a model of spontaneous dopaminergic neurodegenersation is discussed.

TL;DR: The current evidence of relationship between coronary calcification and inflammation is reviewed for purpose of drawing the more attention on the inflammatory mechanism of coronary calcifying, which may change the research as well as therapeutic strategies for coronary calcify in the future.

TL;DR: An increased activity of inhibitory molecules, such as Src homology domain-containing protein tyrosine phosphatase-1 (SHP-1) and suppressors of cytokine signalling (SOCS), is responsible for the age-related failure of GM-CSF to stimulate neutrophil functions via inhibition of Lyn-, phosphoinositide 3-kinase (PI3-K)/extracellular signal-regulated kinase (ERK)- and signal transducers and

TL;DR: This review analyses the influence of apo E polymorphism on blood lipids and CHD in respect to age and finds that at younger ages, death from CHD is influenced by genetic factors, while the genetic effect decreases at older ages where environmental factors may play a more prominent role.

TL;DR: Available survival studies using experimental animals clearly suggest that kidney pathology is one of the important non-neoplastic lesions that could affect overall survival, and that restoration of renal function by preventing kidney damage could significantly extend longevity.

TL;DR: It is suggested that a decline in cellular health status occurs at mid-life, and that this decline may involve a universal or system-specific programmatic shift of signaling control, and may precipitate increased risk of late-life diseases.

TL;DR: The basic concepts and methods for myocardial tissue reconstruction are explored and the progress made and remaining challenges of stem cells in myocardIAL tissue engineering are emphasized.

TL;DR: The role of VPCs in atherogenesis is reviewed, thus providing a novel understanding about the pathophysiology of atherosclerosis and developing novel therapeutic strategies for coronary heart disease.

TL;DR: This review will attempt to integrate the time-related events that occur in the responses of the hypothalamus and the gonads, especially relative to the neuroregulatory systems that have been implicated in the age-related decline in reproductive function.

TL;DR: The duplicate article has therefore been withdrawn and the article is an accidental duplication of an article that has already been published in Ageing Research Reviews.