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Craig N. Robson
Researcher at Newcastle University
Publications - 178
Citations - 10189
Craig N. Robson is an academic researcher from Newcastle University. The author has contributed to research in topics: Prostate cancer & Androgen receptor. The author has an hindex of 56, co-authored 175 publications receiving 9421 citations. Previous affiliations of Craig N. Robson include University of Newcastle & Thomas Jefferson University.
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Journal ArticleDOI
CD133, a novel marker for human prostatic epithelial stem cells
Gavin D. Richardson,Craig N. Robson,Shona H. Lang,David E. Neal,Norman J. Maitland,Anne T. Collins +5 more
TL;DR: In this article, a small population of human prostate basal cells express the cell surface marker CD133 and are restricted to the alpha(2)beta(1)(hi) population, previously identified as a marker of stem cells in prostate epithelia.
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Upregulation and Nuclear Recruitment of HDAC1 in Hormone Refractory Prostate Cancer
TL;DR: Histone deacetylase 1 (HDAC1) is a co‐repressor involved in differentiation and proliferation control and targets a number of transcription factors including p53.
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Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.
TL;DR: It is demonstrated that AR activity is specifically down-regulated by the histone deacetylase activity of HDAC1, and Tip60 directly acetylates the AR, which is a requisite for Tip60-mediated transcription.
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Tip60 is a nuclear hormone receptor coactivator.
Mark E. Brady,Daniel M. Ozanne,Luke Gaughan,Ian Waite,Susan Cook,David E. Neal,Craig N. Robson +6 more
TL;DR: It is shown that Tip60, which was originally identified as a coactivator for the human immunodeficiency virus TAT protein, can enhance AR-mediated transactivation in a ligand-dependent manner in LNCaP and COS-1 cell lines and can also enhance transactivation through the estrogen receptor and progesterone receptor in aligand- dependent manner; thus identifying Tip60 as a nuclear hormone receptor coactivators.
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Cellular functions of TIP60.
TL;DR: It is described how TIP60 is a multifunctional enzyme involved in multiple nuclear transactions, acting in a large multiprotein complex for a range of transcription factors including androgen receptor, Myc, STAT3, NF-kappaB, E2F1 and p53.