C
Cristina Lorenzi
Researcher at Vita-Salute San Raffaele University
Publications - 139
Citations - 6120
Cristina Lorenzi is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Bipolar disorder & Mood disorders. The author has an hindex of 46, co-authored 133 publications receiving 5759 citations. Previous affiliations of Cristina Lorenzi include University of Bologna & Sacred Heart Hospital.
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Brief Research Communication Influence of CLOCK Gene Polymorphism on Circadian Mood Fluctuation and Illness Recurrence in Bipolar Depression
Francesco Benedetti,Alessandro Serretti,Cristina Colombo,Barbara Barbini,Cristina Lorenzi,Euridice Campori,Enrico Smeraldi,San Raffaele +7 more
TL;DR: In this article, the authors investigated the possible role of CLOCK gene polymorphism in the regulation of diurnal mood fluctuations during a major depressive episode and found that the C allele was associated with diurnal preferences of human healthy subjects, with higher "eveningness" in subjects carrying at least one copy of the allele.
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Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression.
Francesco Benedetti,Alessandro Serretti,Cristina Colombo,Barbara Barbini,Cristina Lorenzi,Euridice Campori,Enrico Smeraldi +6 more
TL;DR: A role for the CLOCK gene polymorphism in the regulation of long‐term illness recurrence in bipolar disorder is hypothesized, with a significantly higher recurrence rate in homozygotes for the C variant, which was almost double than that of the other genotype groups.
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Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism.
Alessandro Serretti,Francesco Benedetti,Laura Mandelli,Cristina Lorenzi,Adele Pirovano,Cristina Colombo,Enrico Smeraldi +6 more
TL;DR: Preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP.
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A glycogen synthase kinase 3-β promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression
Francesco Benedetti,Alessandro Serretti,Cristina Colombo,Cristina Lorenzi,Cristina Lorenzi,Viviana Tubazio,Enrico Smeraldi +6 more
TL;DR: Results warrant interest for the variants of genes pertaining to the molecular clock as possible endophenotypes of bipolar disorder, and for GSK3-beta as a target of a new class of antidepressant drugs, but caution ought to be taken in interpreting these preliminary results.
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Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression.
Francesco Benedetti,Sara Dallaspezia,Mara Cigala Fulgosi,Cristina Lorenzi,Alessandro Serretti,Barbara Barbini,Cristina Colombo,Enrico Smeraldi +7 more
TL;DR: O Ongoing lithium treatment significantly interacted with CLOCK 3111 T/C SNP (rs1801260) by enhancing activity levels in the evening and reducing the differences among genotype groups.