C
Cu Nguyen
Researcher at National Institutes of Health
Publications - 43
Citations - 3809
Cu Nguyen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Wnt signaling pathway & Catenin. The author has an hindex of 23, co-authored 41 publications receiving 3287 citations. Previous affiliations of Cu Nguyen include Pacific Northwest Diabetes Research Institute & University of Southern California.
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Journal ArticleDOI
A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription
Katayoon H. Emami,Cu Nguyen,Hong Ma,Dae Hoon Kim,Kwang Won Jeong,Masakatsu Eguchi,Randall T. Moon,Jia-Ling Teo,Se Woong Oh,Hak Yeop Kim,Sung Hwan Moon,Jong Ryul Ha,Michael G. Kahn +12 more
TL;DR: ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.
Journal ArticleDOI
Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression
TL;DR: It is demonstrated that CBP and p300 play very distinct roles in survivin gene transcription, the crucial coactivator for TCF/β-catenin-mediated survivin transcription.
Journal ArticleDOI
Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency
Tomoyuki Miyabayashi,Jia-Ling Teo,Masashi Yamamoto,Michael McMillan,Cu Nguyen,Michael G. Kahn +5 more
TL;DR: It is demonstrated that IQ-1, by targeting the PR72/130 subunit of the serine/threonine phosphatase PP2A, prevents β-catenin from switching coactivator usage from CBP to p300 and is critical for the maintenance of murine stem cell pluripotency.
A small molecule inhibitor of -cateninCREB-binding protein transcription
Katayoon H. Emami,Cu Nguyen,Hong Ma,Dae Hoon Kim,Kwang Won Jeong,Masakatsu Eguchi,Randall T. Moon,Jia-Ling Teo,Se Woong Oh,Hak Yeop Kim,Sung Hwan Moon,Jong Ryul Ha,Michael Kahn +12 more
TL;DR: To identify small molecule antagonists of this pathway, transformed colorectal cells were challenged with a sec-ondary structure-templated chemical library, looking for com-pounds that inhibit -catenin-responsive genes.
Journal ArticleDOI
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.
Samantha Gadd,Vicki Huff,Amy L. Walz,Ariadne H. A. G. Ooms,Amy E. Armstrong,Daniela S. Gerhard,Malcolm A. Smith,Jaime M. Guidry Auvil,Daoud Meerzaman,Qing Rong Chen,Chih Hao Hsu,Chunhua Yan,Cu Nguyen,Ying Hu,Leandro C. Hermida,Tanja M. Davidsen,Patee Gesuwan,Yussanne Ma,Zusheng Zong,Andrew J. Mungall,Richard A. Moore,Marco A. Marra,Jeffrey S. Dome,Charles G. Mullighan,Jing Ma,David A. Wheeler,Oliver A. Hampton,Nicole Ross,Julie M. Gastier-Foster,Stefan T. Arold,Elizabeth J. Perlman +30 more
TL;DR: Integrated analyses support two major classes of genetic changes that preserve the progenitor state and/or interrupt normal development in Wilms tumors.