Palladium-catalyzed alkynylation.

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Manganese(III)-Based Oxidative Free-Radical Cyclizations

The synthesis and structural, photophysical, electrochemical, and electroluminescent properties of a class of platinum(II) complexes bearing σ-alkynyl ancillary ligands, namely [(C∧N∧N)Pt(C⋮C)nR] [H(C∧N∧N) = 6-aryl-2,2‘-bipyridine; n = 1−4; R = aryl, alkyl, or trimethylsilyl], have been studied. Substituents with different steric and electronic properties were introduced into the tridentate cyclometalating and arylacetylide ligands, and the π-conjugation length of the oligoynyl moiety was homologously extended from ethynyl to octatetraynyl. The X-ray crystal structures of several derivatives confirm the Pt−(C⋮C) ligation and reveal various intermolecular interactions, such as π−π, Pt···Pt, and C−H···F−C. The complexes display good thermal stability and intense phosphorescence in fluid and glassy solutions with high quantum yields and microsecond lifetimes. Their emission energies are sensitive to solvent polarity, the electronic affinities of the substituents on both the cyclometalating and arylacetylide ...

Light-Emitting Tridentate Cyclometalated Platinum(II) Complexes Containing σ-Alkynyl Auxiliaries: Tuning of Photo- and Electrophosphorescence

The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

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HIV integrase inhibitors

Over the past fifty years, hundreds of polyyne compounds have been isolated from nature. These often unstable molecules are found in sources as common as garden vegetables and as obscure as bacterial cultures. Naturally occurring polyynes feature a wide range of structural diversity and display an equally broad array of biological properties. Early synthetic efforts relied primarily on Cu-catalyzed, oxidative acetylenic homo- and heterocoupling reactions to assemble the polyyne framework. The past 25 years, however, have witnessed a renaissance in the field of polyyne natural product synthesis: transition-metal-catalyzed alkynylation reactions and asymmetric transformations have combined to substantially expand access to natural polyynes. This Review recounts these synthetic achievements and also highlights both the natural source(s) and biological relevance for many of these compounds.

Synthesis of Naturally Occurring Polyynes

Synthesis of a Calicheamicin Deoxyaglycone Model by an Intramolecular Acetylide Cyclization

Synthese a partir de composes acetyleniques et de dichloro-1,2 ethylene en presence d'un complexe du palladium (0) via des composes enyniques

Cynthia A. Smith

Papers

Synthesis of a Calicheamicin Deoxyaglycone Model by an Intramolecular Acetylide Cyclization

A mild synthesis of 1,3-diynes

Intramolecular radical cyclization of phenolic enolates

Intramolecular Radical Cyclization of Phenolic Enolates.

A Mild Synthesis of 1,3-Diynes.