C
Cyril Boyault
Researcher at French Institute of Health and Medical Research
Publications - 8
Citations - 1237
Cyril Boyault is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Ubiquitin & Acetylation. The author has an hindex of 6, co-authored 8 publications receiving 1123 citations. Previous affiliations of Cyril Boyault include Joseph Fourier University.
Papers
More filters
Journal ArticleDOI
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.
Cyril Boyault,Yu Zhang,Sabrina Fritah,Cécile Caron,Benoit Gilquin,So Hee Kwon,Carmen Garrido,Tso-Pang Yao,Claire Vourc'h,Patrick Matthias,Saadi Khochbin +10 more
TL;DR: The data show that HDAC6 senses ubiquitinated cellular aggregates and consequently induces the expression of major cellular chaperones by triggering the dissociation of a repressive HDAC 6/HSF1/HSP90 (heat-shock protein 90) complex and a subsequent HSF1 activation, andHDAC6 appears as a master regulator of the cell protective response to cytotoxic protein aggregate formation.
Journal ArticleDOI
HDAC6–p97/VCP controlled polyubiquitin chain turnover
Cyril Boyault,Benoit Gilquin,Yu Zhang,Vladimir Rybin,Elspeth F. Garman,Wolfram Meyer-Klaucke,Patrick Matthias,Christoph W. Müller,Saadi Khochbin +8 more
TL;DR: It is proposed that a finely tuned balance of HDAC6 and p97/VCP concentrations determines the fate of ubiquitinated misfolded proteins: p97 /VCP would promote protein degradation and ubiquitin turnover, whereasHDAC6 would favour the accumulation of ubiquITinated protein aggregates and inclusion body formation.
Journal ArticleDOI
Regulatory cross-talk between lysine acetylation and ubiquitination: role in the control of protein stability.
TL;DR: Analysis of the underlying mechanisms shows that, besides a direct competition between the two lysine modifications, more complex and indirect processes also connect these two signalling pathways.
Journal ArticleDOI
Regulation of protein turnover by acetyltransferases and deacetylases
Karin Sadoul,Cyril Boyault,Cyril Boyault,Michel Pabion,Michel Pabion,Saadi Khochbin,Saadi Khochbin +6 more
TL;DR: Observations reveal a tight link between protein lysine acetylation and ubiquitination and designate theacetylation machinery as a determinant element in the control of cellular proteolytic activities.
Journal ArticleDOI
Heat-Shock Factor 1 Controls Genome-wide Acetylation in Heat-shocked Cells
Sabrina Fritah,Edwige Col,Cyril Boyault,Jérôme Govin,Karin Sadoul,Susanna Chiocca,Elisabeth S. Christians,Saadi Khochbin,Caroline Jolly,Claire Vourc'h +9 more
TL;DR: HSF1 is identified as a master regulator of global chromatin acetylation and a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock is revealed.