D
D. Bengel
Researcher at University of Würzburg
Publications - 23
Citations - 10298
D. Bengel is an academic researcher from University of Würzburg. The author has contributed to research in topics: Serotonin transporter & Serotonergic. The author has an hindex of 15, co-authored 23 publications receiving 10079 citations. Previous affiliations of D. Bengel include National Institutes of Health.
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Journal ArticleDOI
Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
Klaus-Peter Lesch,D. Bengel,Armin Heils,Sue Z. Sabol,Benjamin D. Greenberg,Susanne Petri,Jonathan Benjamin,Clemens R. Müller,Dean H. Hamer,Dennis L. Murphy +9 more
TL;DR: The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5HTT expression and 5HT uptake in lymphoblasts as discussed by the authors, which is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs.
Journal ArticleDOI
Allelic Variation of Human Serotonin Transporter Gene Expression
Armin Heils,A. Teufel,Susanne Petri,Gerald Stöber,Peter Riederer,D. Bengel,Klaus-Peter Lesch +6 more
TL;DR: Mood, emotion, cognition, and motor functions as well as circadian and neuroendocrine rhythms, including food intake, sleep, and reproductive activity, are modulated by the midbrain raphe serotonin (5‐HT) system and allele‐dependent differential 5‐HTT promoter activity may play a role in the expression and modulation of complex traits and behavior.
Journal ArticleDOI
Altered Brain Serotonin Homeostasis and Locomotor Insensitivity to 3,4-Methylenedioxymethamphetamine (“Ecstasy”) in Serotonin Transporter-Deficient Mice
D. Bengel,Dennis L. Murphy,Anne M. Andrews,Christine Wichems,Douglas Feltner,Armin Heils,Rainald Mössner,Heiner Westphal,Klaus-Peter Lesch +8 more
TL;DR: Data suggest that the presence of a functional 5-HTT is essential for brain 5- HT homeostasis and for 3,4-methylenedioxymethamphetamine-induced hyperactivity.
Journal Article
A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders
David A. Collier,Gerald Stöber,Tao Li,Armin Heils,Marco Catalano,D. Di Bella,Maria Arranz,Robin M. Murray,Homero Vallada,D. Bengel,Clemens R. Müller,G.W. Roberts,Enrico Smeraldi,George Kirov,Pak C. Sham,Klaus-Peter Lesch +15 more
TL;DR: It is suggested that 5-HTTLPR-dependent variation in functional 5- HTT expression is a potential genetic susceptibility factor for affective disorders.
Journal ArticleDOI
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets.
TL;DR: 5-HT uptake findings support a functional difference in the two 5-HTTLPR variants, reinforcing their attractiveness as candidate genes in neuropsychiatric research.