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Klaus-Peter Lesch

Researcher at University of Würzburg

Publications -  537
Citations -  55097

Klaus-Peter Lesch is an academic researcher from University of Würzburg. The author has contributed to research in topics: Serotonin transporter & Serotonergic. The author has an hindex of 106, co-authored 524 publications receiving 50099 citations. Previous affiliations of Klaus-Peter Lesch include Maastricht University Medical Centre & I.M. Sechenov First Moscow State Medical University.

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Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

TL;DR: The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5HTT expression and 5HT uptake in lymphoblasts as discussed by the authors, which is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs.
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Allelic Variation of Human Serotonin Transporter Gene Expression

TL;DR: Mood, emotion, cognition, and motor functions as well as circadian and neuroendocrine rhythms, including food intake, sleep, and reproductive activity, are modulated by the midbrain raphe serotonin (5‐HT) system and allele‐dependent differential 5‐HTT promoter activity may play a role in the expression and modulation of complex traits and behavior.
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

S. Hong Lee, +405 more
- 01 Sep 2013 - 
TL;DR: Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
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Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.