D. Bochicchio

TL;DR: It is demonstrated that transsphenoidal surgery is a safe and effective treatment for patients with Cushing's disease, however, after successful surgery there is a steady increase in the percentage of recurrences, which continues with time.

TL;DR: The results suggest that patients with constitutively active adenylyl cyclase have hyperactive tumors; the sensitivity of these tumors to inhibitory agents (somatostatin and dopamine), possibly counteracting the expression of activating mutations, might explain the low rate of tumor growth.

TL;DR: The acute administration of somatostatin or octreotide is not able to modify ACTH levels in patients with corticotropin hypersecretion either due to hypo-cortisolemic state or consequent to ACTH-secret-ing pituitary or ectopic tumors; moreover,Octreotide does not affect the pituitARY-adrenal responsiveness to CRH in patientswith Cushing’s disease.

TL;DR: Oral Zn administration in patients with CRF significantly increases both total and Zn-bound thymulin, but does not modify basal and TRH-stimulated serum PRL levels, suggesting that Zn is a potent stimulus for thymic hormone synthesis, and it can reverse the age-related diminution ofThymic activity in CRF patients.

TL;DR: 6 women affected with pituitary adenomas, without evident clinical features of hypercortisolism, in whom retrospective data suggested the possibility of clinically diagnosing silent corticotropinomas in vivo are described, to suggest the occurrence of ACTH/ cortisol hyperresponsiveness to CRH and/or lysine-vasopressin and the lack of suppression of ACT hortisol secretion to opioid agonists in patients with apparently “nonfunctioning” pit