L
Lucia Vallar
Researcher at University of Milan
Publications - 39
Citations - 5038
Lucia Vallar is an academic researcher from University of Milan. The author has contributed to research in topics: G protein & Receptor. The author has an hindex of 25, co-authored 39 publications receiving 4949 citations. Previous affiliations of Lucia Vallar include University of Geneva & Università telematica San Raffaele.
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Journal ArticleDOI
GTPase inhibiting mutations activate the α chain of G s and stimulate adenylyl cyclase in human pituitary tumours
TL;DR: A subset of growth hormone-secreting human pituitary tumours carries somatic mutations that inhibit GTPase activity of a G protein α chain, αs, which results in the activation of adenylyl cyclase, which bypasses the cells' normal requirement for trophic hormone.
Journal ArticleDOI
Two G protein oncogenes in human endocrine tumors
John Lyons,Claudia A. Landis,Claudia A. Landis,Griffith R. Harsh,Lucia Vallar,Kurt Grünewald,Hans Feichtinger,Quan-Yang Duh,Orlo H. Clark,Ernest S. Kawasaki,Henry R. Bourne,Henry R. Bourne,Frank McCormick +12 more
TL;DR: Findings suggest that human tumors may harbor oncogenic mutations in various G protein alpha chain genes, referred to as gip2.
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Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas.
TL;DR: A profoundly altered Gs protein is found in a group of human growth hormone-secreting pituitary adenomas, characterized by high secretory activity and intracellular cyclic AMP levels.
Journal ArticleDOI
Mechanisms of signal transduction at the dopamine D2 receptor.
Lucia Vallar,Jacopo Meldolesi +1 more
TL;DR: A spectrum of intracellular signals is analyzed which might be sufficient to sustain inhibition of secretion in pituitary lactotroph cells and possibly the other effects of D2 receptors in other cell systems.
Journal ArticleDOI
Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase
Anna Spada,Maura Arosio,D. Bochicchio,Nicoletta Bazzoni,Lucia Vallar,Monique Bassetti,Giovanni Faglia +6 more
TL;DR: The results suggest that patients with constitutively active adenylyl cyclase have hyperactive tumors; the sensitivity of these tumors to inhibitory agents (somatostatin and dopamine), possibly counteracting the expression of activating mutations, might explain the low rate of tumor growth.